Arboviruses are transmitted by blood-sucking arthropods and infect vertebrates through insect bites. Its global prevalence and recurrence threaten human life and health. However, the pathogenic mechanism has not yet been fully elucidated. Neutrophils, as the most numerous leukocytes in the body, are the first to arrive at the site of infection after pathogen invasion, and play a role in the immune response through a variety of anti-infective mechanisms, including phagocytosis of pathogens, production of cytokines and antimicrobial substances, respiratory outbreaks, and secretion of NETs, which is an important member of the body's defence against pathogenic microorganisms. However, it is worth noting that excessive activation of neutrophils may also lead to a strong inflammatory response, which not only fails to control the infection effectively, but also causes damage to host tissues and further aggravates the severity of the infection. Previous knowledge of the role of neutrophils was mostly limited to fighting bacterial and fungal infections. However, it is only in recent years that their role in antivirus has been gradually revealed and valued. Therefore, its role and mechanism in controlling arboviral infections are not yet clear. In this paper, we present an overview of the role of neutrophils in arboviral infections and their possible effects on the host.
The role of neutrophils in arbovirus infections[J]. Journal of Microbes and Infections. 2025, 20(3): 173-181
中图分类号:
R373
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