岩藻多糖拮抗幽门螺杆菌感染及调节肠道菌群的作用机制

李梦如 王海强

微生物与感染 ›› 2025, Vol. 20 ›› Issue (3) : 182-192.

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微生物与感染 ›› 2025, Vol. 20 ›› Issue (3) : 182-192.
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岩藻多糖拮抗幽门螺杆菌感染及调节肠道菌群的作用机制

  • 李梦如,王海强
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The mechanism of action of fucoidan in antagonizing Helicobacter pylori infection and regulating gut microbiota

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摘要

幽门螺杆菌(Helicobacter pylori,Hp)作为一种常见的胃部病原体,全球感染率居高不下,是导致胃炎、胃溃疡、胃癌等多种胃肠道疾病的主要病因。根除Hp感染的治疗方法,不仅改善了其引起的与胃部炎症和肠道菌群紊乱相关的疾病,还降低了胃癌的风险。然而,随着抗生素的广泛使用,Hp的耐药性不断升高,增加了治疗的失败率,因此迫切需要寻找新的治疗方案或辅助治疗药物。岩藻多糖(Fucoidan)因其独特的生物学功能和广泛的应用领域而备受瞩目。研究发现Fucoidan对Hp感染相关的胃炎症和肠道菌群紊乱具有治疗及预防作用。本文阐述了Fucoidan在拮抗Hp感染中的主要作用及相关机制,包括直接抑制、减轻炎症反应、增强抗氧化能力及调节肠道菌群,为其成为治疗Hp感染的有效药物提供了理论依据,旨在将其纳入根除Hp感染的治疗计划。

Abstract

Helicobacter pylori (Hp), as a common gastric pathogen, has a high global infection rate and is the main cause of various gastrointestinal diseases such as gastritis, gastric ulcers, and gastric cancer. The treatment of eradicating Hp infection NOt only improves the diseases related to gastric inflammation and intestinal microbiota disorders caused by it, but also reduces the risk of gastric cancer. However, with the widespread use of antibiotics, the resistance of Hp continues to rise, increasing the failure rate of treatment. Therefore, there is an urgent need to find new treatment options or adjuvant drugs. Fucoidan has attracted much attention due to its unique biological functions and wide application fields. Research has found that Fucoidan has therapeutic and preventive effects on Hp infection related gastritis and intestinal microbiota disorders. This article elaborates on the main role and related mechanisms of Fucoidan in antagonizing Hp infection, including direct inhibition, reduction of inflammatory response, enhancement of antioxidant capacity, and regulation of gut microbiota. It provides a theoretical basis for Fucoidan to become an effective drug for treating Hp infection and aims to incorporate it into the treatment plan for eradicating Hp infection.

关键词

岩藻多糖 / 幽门螺杆菌 / 中药多糖 / 肠道菌群 / 益生元

Key words

Fucoidan / Helicobacter pylori / Chinese herbal polysaccharides / Gut microbiota / prebiotics

引用本文

导出引用
李梦如 王海强. 岩藻多糖拮抗幽门螺杆菌感染及调节肠道菌群的作用机制[J]. 微生物与感染. 2025, 20(3): 182-192
The mechanism of action of fucoidan in antagonizing Helicobacter pylori infection and regulating gut microbiota[J]. Journal of Microbes and Infections. 2025, 20(3): 182-192
中图分类号: R2   

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