Rcs是肠杆菌科细菌中的一种复杂的双组分信号转导系统，能调节细菌荚膜异多糖酸合成，以及细菌鞭毛基因、抗酸性基因等的表达。Rcs不同于典型的双组分系统，其由3个蛋白构成，磷酸转移过程分3步进行。不同细菌中的Rcs功能有所区别，主要为调控细菌的毒力和应激。本文在简单介绍细菌双组分信号转导系统的基础上，重点对肠杆菌科细菌Rcs的组成、功能及磷酸转移机制进行综述。

Rcs is a complex two-component system in Enterobacteriaceae bacteria. It regulates the synthesis of bacterial colanic acids, and the expressions of bacterial flagella genes and resistance genes. Distinguished with typical two-component systems, Rcs consists of three components, among which phosphate group is transferred via three steps. Rcs in different species may possess its own distinct functions, mainly in the regulation of bacterial virulence and stress control. This review focuses on the components, function and signal transduction mechanisms of Rcs system.