为探讨老年大肠埃希菌血流感染患者的临床特点及药敏结果，回顾性分析徐州医科大学附属医院2013年1月—2016年12月340例大肠埃希菌血流感染老年患者的临床资料及药敏结果，采用SPSS软件进行分析。结果显示，患者均合并基础疾病(恶性肿瘤、高血压病、糖尿病、肺部感染等)；感染途径主要为消化道(38.5%)、呼吸道(36.8%)和泌尿道(22.6%)；检出产超广谱β-内酰胺酶(extended-spectrum β-lactamase，ESBL)大肠埃希菌96例(28.2%)；ESBL阳性菌对氨苄西林、复方磺胺甲恶唑、环丙沙星、哌拉西林、第3代头孢、左氧氟沙星的耐药率均高；所有菌株均对碳青霉烯类敏感。结果提示，该院老年大肠埃希菌血流感染患者均合并基础疾病，常见感染途径是消化道、呼吸道和泌尿道，ESBL阳性大肠埃希菌除对碳青霉烯类抗菌药物敏感外，对多种抗菌药物耐药。

The aim of this study is to investigate the clinical features and drug sensitivity of elderly patients with bloodstream infection by Escherichia coli (E. coli) . The medical records of 340 elderly patients with E. coli infection in The Affiliated Hospital of Xuzhou Medical University from January 2013 to December 2016 were retrospectively analyzed. SPSS software was used for analysis. The results showed that the patients were all associated with underlying diseases (malignant diseases, hypertension, diabetes, lung infections, etc.). The main routes of infection were digestive tract (38.5%), respiratory tract (36.8%) and urinary tract (22.6%). Extended-spectrum β-lactamase (ESBL)-producing E. coli strains were detected in 96 cases (28.2%). The isolated strains were mostly resistant to ampicillin, chemitrim ciprofloxacin, piperacillin, the 3rd generation of cephalosporins, and levofloxacin, but were sensitive to carbapenems.