杆菌细胞形变的机制与功能

王蕾1; *; 邹琳1; *; 李梦洁1; 侯琳琳1; 陈小明2; 刘伟2; 孙桂芹3; 陈力1

doi:10.3969/j.issn.1673-6184.2019.01.005

微生物与感染 >

2019 , Vol. 14 >Issue 2: 99 - 105

DOI: https://doi.org/10.3969/j.issn.1673-6184.2019.01.005

综述

杆菌细胞形变的机制与功能

王蕾1 ,
* ,
邹琳1 ,
* ,
李梦洁1 ,
侯琳琳1 ,
陈小明2 ,
刘伟2 ,
孙桂芹3 ,
陈力1

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1. 复旦大学基础医学院医学分子病毒学教育部/卫生部重点实验室，上海 200032; 2. 浙江省水利水电装备表面工程技术研究重点实验室，浙江杭州 310024; 3. 浙江中医药大学医学技术学院，浙江杭州 310053

收稿日期: 2018-09-03

网络出版日期: 2019-04-25

基金资助

国家新药创制重大专项(2014ZX09101-046-004)，国家自然科学基金(31600644)，浙江省水利水电装备表面工程技术研究重点实验室开放基金(2017SLKL004)

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Morphological transformation of rod-shaped bacterial cells: mechanisms and biological impacts

WANG Lei1 ,
* ,
ZOU Lin1 ,
* ,
LI Mengjie1 ,
HOU Linlin1 ,
CHEN Xiaoming2 ,
LIU Wei2 ,
SUN Guiqin3 ,
CHEN Li1

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1. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Key Laboratory of Research on Hydraulic and Hydro-Power Equipment Surface Engineering Technology of Zhejiang Province, Hangzhou 310024, Zhejiang Province, China; 3. College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China

Received date: 2018-09-03

Online published: 2019-04-25

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摘要

细菌的形态是细菌分类与鉴定的核心指标。虽然在分类上细菌的基本形态有球形、杆状、弧形和螺旋形，但在不同生理和病理条件下细菌的形态会发生改变。本文对细菌的基本形态转变和杆菌的丝状形变分子机制进行了概述，并归纳了在营养缺乏、放射污染、对抗宿主免疫系统和抗生素处理等条件下细菌产生形态改变的生物学及临床意义。

关键词： 形变; 丝状形变; 逃逸宿主免疫系统; 抗生素耐药

本文引用格式

王蕾1 , * , 邹琳1 , * , 李梦洁1 , 侯琳琳1 , 陈小明2 , 刘伟2 , 孙桂芹3 , 陈力1 . 杆菌细胞形变的机制与功能[J]. 微生物与感染, 2019 , 14(2) : 99 -105 . DOI: 10.3969/j.issn.1673-6184.2019.01.005

Abstract

Cell shape is a basic core feature for bacterial classification and identification. Although a bacterium could be defined as coccus, bacillus, vibrio or spirochete, morphological transformations were observed under various physiological and pathological conditions. In this paper, the molecular mechanisms of rod-shaped bacterial morphological transformation are reviewed, and the biological impacts of morphological transformation under nutritional deficiency, radiation, antibiotic treatment and attacking by host immune systems are discussed.

Key words： Morphological transformation; Filamentation; Escape from host immune system; Antibioticresistance

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