本文旨在通过探讨新生儿李斯特菌病的临床特点、治疗及预后，明确母体危险因素，为新生儿产单核细胞李斯特菌(下称李斯特菌)感染的临床诊断和治疗提供依据。回顾性分析2011年5月－2018年4月西北妇女儿童医院新生儿科诊治的18例李斯特菌感染新生儿及其母亲的发病情况、临床表现、实验室指标、影像学检查、治疗及预后，发现18例产妇中15例有临床症状，以发热及不规则腹痛最为常见；患儿中13例有临床症状，多数表现为呼吸窘迫和发热；89%患儿发生血流感染(61%为化脓性脑膜炎、28%为肺炎)；影像学检查提示，存活患儿中56%有神经系统后遗症，50%可能有先天性心脏病。14例在明确李斯特菌感染后调整抗生素治疗，所有产妇经治疗均预后良好；患儿除1例放弃治疗、3例要求出院外，其余14例均痊愈或好转出院。新生儿李斯特菌感染是一种严重的感染性疾病，因此对有发热、腹痛及早产症状的孕妇，应警惕李斯特菌感染，尽早进行病原学检测和目标性治疗，以改善预后。

The aim of this paper was to describe the clinical characteristics, treatment, and outcomes of neonatal Listeria infection. A total of 18 cases of perinatal listeriosis treated in Northwest Women’s and Children’s Hospital from May 2011 to April 2018 were included. Maternal history, perinatal events, clinical features, laboratory findings, treatment and prognosis were retrospectively reviewed. The results showed that 15 of the 18 mothers had clinical symptoms, such as fever and irregular abdominal pain. 13 newborns had clinical symptoms, mostly with respiratory distress and fever. 89% of the newborns developed bacteremia (61% with meningitis and 28% with pneumonia). Imaging examination indicated that 56% of the survival neonates had neurologic sequelae and 50% were likely to have congenital heart disease. Anti-infection medications were adjusted in 14 cases after the diagnosis of septicemia. All the pregnant women had a good prognosis. The neonates were discharged after recovery except one who gave up treatment and three whose parents requested for discharge. As listeriosis is a serious infectious disease in neonates, pregnant women with fever, abdominal pain and preterm labor should be alert to listeria infection, and early detection and targeted treatment can help improve the prognosis.