诺如病毒的致病机制及诊断

周弘璐1; 谭明2; 3; 汪萱怡1; 4

doi:10.3969/j.issn.1673-6184.2019.05.007

微生物与感染 >

2019 , Vol. 14 >Issue 5: 303 - 309

DOI: https://doi.org/10.3969/j.issn.1673-6184.2019.05.007

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诺如病毒的致病机制及诊断

周弘璐1 ,
谭明2 ,
3 ,
汪萱怡1 ,
4

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1. 复旦大学上海医学院基础医学院教育部、卫健委、医科院医学分子病毒学重点实验室，上海 200032; 2. 辛辛那提儿童医院医学中心传染病室，辛辛那提，俄亥俄州，美国； 3. 辛辛那提大学医学院儿科系，辛辛那提，俄亥俄州，美国； 4. 复旦大学附属儿科医院，上海 201102

收稿日期: 2019-05-06

网络出版日期: 2019-10-25

基金资助

国家“重大新药创制”科技重大专项(2018ZX09739002-006)

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Pathogenesis and diagnosis of norovirus

ZHOU Honglu1 ,
TAN Ming2 ,
3 ,
WANG Xuanyi1 ,
4

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1. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS)，School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; 4. Children’s Hospital of Fudan University, Shanghai 201102, China

Received date: 2019-05-06

Online published: 2019-10-25

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摘要

诺如病毒(Norovirus, NoV)是引起全人群急性胃肠炎暴发和流行的主要病原体，也是引起食源性疾病的最常见非细菌性病原体。由于缺少有效的小型动物及培养细胞研究模型，目前对NoV感染的致病机制尚不清楚。NoV实验室诊断技术发展成熟，尤其是近年来新技术的应用将进一步推动其诊断水平的提高，满足公共卫生和临床诊疗的新需求。

关键词： 诺如病毒; 致病机制; 实验室诊断

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周弘璐1 , 谭明2 , 3 , 汪萱怡1 , 4 . 诺如病毒的致病机制及诊断[J]. 微生物与感染, 2019 , 14(5) : 303 -309 . DOI: 10.3969/j.issn.1673-6184.2019.05.007

Abstract

Noroviruses are the most important viral pathogens causing epidemic acute gastroenteritis infecting people of all ages around the world. The viruses are responsible for the most common non-bacterial foodborne outbreaks of diarrhea. Due to the lack of an effective cell culture or small animal research model, the pathogenesis of norovirus infection and illness remains unclear. By contrast, norovirus laboratory diagnostic technologies are well developed. The recent applications of new technologies are further enhancing the development of diagnostic tools to meet the needs of public health and clinical diagnosis and treatment.

Key words： Norovirus; Pathogenesis; Laboratory diagnosis

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