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综述

带状疱疹疫苗的研究进展及应用

  • 李计来 ,
  • 徐静
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  • 国药中生生物技术研究院有限公司第三研究室,北京 101111

收稿日期: 2019-08-28

  网络出版日期: 2020-06-25

Research and application of herpes zoster vaccine

  • LI Jilai ,
  • XU Jing
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  • No.3 Research Laboratory, National Vaccine and Serum Institute, Bejing 101111, China

Received date: 2019-08-28

  Online published: 2020-06-25

摘要

带状疱疹是由潜伏在体内的水痘-带状疱疹病毒再激活引起的一种急性皮肤病,主要发生于老年人和免疫力低下人群。带状疱疹是一种自限性疾病,临床主要表现为带状、成片的皮疹,而其后遗神经痛为该病中最复杂且最常见的一种不良并发症。带状疱疹的发病机制较为复杂,推测与机体的特异性T细胞免疫水平降低有关。本文就带状疱疹与T细胞之间的关系,最新疫苗研究进展进行综述,为疫苗的研发及带状疱疹的预防提供参考。

本文引用格式

李计来 , 徐静 . 带状疱疹疫苗的研究进展及应用[J]. 微生物与感染, 2020 , 15(3) : 186 -191 . DOI: 10.3969/j.issn.1673-6184.2020.03.008

Abstract

Herpes zoster is an acute skin disease caused by relapse of varicella-zoster virus, which mainly occurs in the elderly and people with low immunity. Herpes zoster is a self-limiting disease characterized by rashes. Postherpetic neuralgia is the most complex and common adverse complication of herpes zoster. The pathogenesis of herpes zoster is complex, presumably related to T cell immunity. In this paper, the relationship between herpes zoster and T cells is reviewed, and the latest vaccine research is reviewed, which can provide reference for vaccine development and prevention of herpes zoster.
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