从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用

杨浩1; 2; 邬永琳1; 2; 荣星喻1; 2; 严雨晨1; 2; 汪慧菁3; 牛辰1; 2; 赵超1; 2

doi:10.3969/j.issn.1673-6184.2020.02.006

微生物与感染 >

2020 , Vol. 15 >Issue 2: 104 - 107

DOI: https://doi.org/10.3969/j.issn.1673-6184.2020.02.006

综述

从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用

杨浩1 ,
2 ,
邬永琳1 ,
2 ,
荣星喻1 ,
2 ,
严雨晨1 ,
2 ,
汪慧菁3 ,
牛辰1 ,
2 ,
赵超1 ,
2

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1. 复旦大学上海医学院基础医学院教育部/卫健委/医科院医学分子病毒学重点实验室，上海 200032; 2. 国家老年疾病临床医学研究中心(复旦大学附属华山医院)，上海 200040; 3. 上海健康医学院神经精神药理学实验室，上海 201318

收稿日期: 2020-02-11

网络出版日期: 2020-04-25

基金资助

“十三五”国家重点研发计划(2018YFC2000503，2018YFC2000500)，复旦大学卓学计划(2015)，上海医学院卿枫计划

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Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota

YANG Hao1 ,
2 ,
WU Yonglin1 ,
2 ,
RONG Xingyu1 ,
2 ,
YAN Yuchen1 ,
2 ,
WANG Huijing3 ,
NIU Chen1 ,
2 ,
ZHAO Chao1 ,
2

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1. MOE/NHC/CAMS Key Laboratory of Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan university, Shanghai 200032, China; 2. National Clinical Research Center on Aging and Medicine, Huashan Hospital, Shanghai 200040, China; 3. Laboratory of Neuropsychopharmacology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

Received date: 2020-02-11

Online published: 2020-04-25

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摘要

2019冠状病毒病(coronavirus disease 2019，COVID-19)的病原学和临床表现多有报道。该病在病原学和临床表现上与发生在2003年的严重急性呼吸综合征(severe acute respiratory syndrome, SARS)有诸多相似性。本文通过对比两者异同，尝试从其共同受体血管紧张素转换酶2(angiotensin converting enzyme 2，ACE2)角度，提出并探讨患者肠道菌群可能参与其致病的潜在机制，旨在为深入探索新型冠状病毒，即严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)的致病机制及加速研发重症肺炎预测指标提供一种可能的新思路。

关键词： 肠道菌群; 2019冠状病毒病; 严重急性呼吸综合征; 血管紧张素转换酶2

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杨浩1 , 2 , 邬永琳1 , 2 , 荣星喻1 , 2 , 严雨晨1 , 2 , 汪慧菁3 , 牛辰1 , 2 , 赵超1 , 2 . 从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用[J]. 微生物与感染, 2020 , 15(2) : 104 -107 . DOI: 10.3969/j.issn.1673-6184.2020.02.006

Abstract

Since the out breaking of coronavirus induced disease 2019 (COVID-19), the etiology and clinical manifestations of the disease have been reported and analyzed. There are many similarities between the etiology and clinical manifestations of the SARS in 2003. By comparing the similarities and differences between them, this study attempts to put forward and explore the potential mechanism of gut microbiota in patients, which may participate in its pathogenesis from the perspective of the shared receptor angiotensin converting enzyme 2 (ACE2). It may provide a possible way for in-depth study of the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) and the development of prediction indicators for severe pneumonia.

Key words： Gut microbiota; Coronavirus disease 2019; Severe acute respiratory syndrome; Angiotensin converting enzyme 2

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