鼠疫曾给人类带来3次世界性灾难，剥夺了上亿人的生命。作为危害人类健康最为严重的烈性传染病之一，鼠疫的防控工作显得尤为重要。新中国成立后，党和政府大力开展鼠疫防控工作，开展流行病调查，制定各项防控措施。虽然全国范围在较短的时间内遏制了鼠疫流行的猛烈势头，但在西部地区人间鼠疫时有发生。青海省地处我国西部，就其鼠疫流行特征制定了适合本地鼠疫的防控模式。本文就“青海模式”的工作机制、调查监测、宣传教育、人员培训、隐患排查等进行介绍，阐述青海省鼠疫防控工作的成效，为中国传染病防控策略发展提出新的思考。

The plague, caused by Yersinia pestis, has caused three world-wide disasters to human beings and hundreds of millions of people’s death historically. As one of the most serious severe infectious diseases, the prevention and control of plague in China is particularly important. In China, prevention and control of plague have been carried out intensively by the government , including promoting epidemiological investigations and formulating various prevention and control measures. The fierce momentum of the plague epidemic nationwide had been curbed in a short period, nevertheless, the plague epidemic had never been eliminated and still had been broken out in western China because of the presence of the host of Yersinia pestis. Based on the epidemic situation of plague, we summarized prevention and control mode of plague in Qinghai province . In this article, we introduce the “Qinghai Model” for plague preventing and controlling, specifically including way of working, platform constructing, public educating, investigating and monitoring, staff training, eliminating of hidden danger, and ecological civilization constructing etc.. It has effectively controlled plague prevalence in Qinghai. Itwill provide new strategy for the development and countermeasures of plague prevention and control in Qinghai province.