沙门菌逃逸宿主天然免疫应答机制的研究进展

徐诺1; 周帮月1; 史艺1; 潘兴元1; 2; 秦涛3; 徐正中4; 阴银燕1; 2; 4

doi:10.3969/j.issn.1673-6184.2020.05.010

微生物与感染 >

2020 , Vol. 15 >Issue 5: 331 - 336

DOI: https://doi.org/10.3969/j.issn.1673-6184.2020.05.010

综述

沙门菌逃逸宿主天然免疫应答机制的研究进展

徐诺1 ,
周帮月1 ,
史艺1 ,
潘兴元1 ,
2 ,
秦涛3 ,
徐正中4 ,
阴银燕1 ,
2 ,
4

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1. 扬州大学医学院(转化医学研究院), 扬州 225009; 2. 江苏省非编码RNA基础与临床转化重点实验室，扬州 225009; 3. 江苏省动物重要疫病与人兽共患病防控协同创新中心，扬州大学兽医学院，扬州 225009; 4. 江苏省人兽共患病学重点实验室，扬州 225009

收稿日期: 2020-02-21

网络出版日期: 2020-10-25

基金资助

国家自然科学基金(31600113)，江苏省人兽共患病学重点实验室资助项目(R1909)，江苏高校优势学科建设工程(PAPD)资助项目

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Current research progress on host innate immune escaping by Salmonella

XU Nuo1 ,
ZHOU Bangyue1 ,
SHI Yi1 ,
PAN Xingyuan1 ,
2 ,
QIN Tao3 ,
XU Zhengzhong4 ,
YIN Yinyan1 ,
2 ,
4

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1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 2. Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 4. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, China

Received date: 2020-02-21

Online published: 2020-10-25

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摘要

沙门菌是重要的食源性病原菌，其流行严重威胁着全球公共卫生安全。天然免疫应答对于宿主抵御沙门菌的感染具有重要的作用，但是沙门菌已演化出一系列逃逸宿主天然免疫应答的策略，使其在宿主体内定植，并得以持续性感染。本文对由受体(TLRs、NLRs和RIPs)、细胞因子(IL-22和IL-4)和哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin，mTOR)信号通路介导的沙门菌逃逸天然免疫应答的机制研究进展进行阐述，期望为沙门菌的预防与治疗提供新的研究思路。

关键词： 沙门菌; 免疫逃逸; Toll样受体; 核苷酸结合寡聚化结构域样受体; 细胞因子; 哺乳动物西罗莫司靶蛋白信号通路

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徐诺1 , 周帮月1 , 史艺1 , 潘兴元1 , 2 , 秦涛3 , 徐正中4 , 阴银燕1 , 2 , 4 . 沙门菌逃逸宿主天然免疫应答机制的研究进展[J]. 微生物与感染, 2020 , 15(5) : 331 -336 . DOI: 10.3969/j.issn.1673-6184.2020.05.010

Abstract

Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.

Key words： Salmonella; Immune evasion; Toll like receptor; Nucleotide binding oligomerization domain like receptor; Cytokines; Mammalian target of rapamycin signaling pathway

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