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综述

脑膜炎败血伊丽莎白菌及其感染的研究进展

  • 陆怡凯1 ,
  • 袁舒颖1 ,
  • 杨源博1 ,
  • 巫祺乐1 ,
  • 方子璇1 ,
  • 刘岩1 ,
  • 陈力2 ,
  • 孙桂芹1
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  • 1. 浙江中医药大学医学技术与信息工程学院,浙江 杭州310053; 2. 复旦大学基础医学院病原生物学系,教育部/卫健委/医科院医学分子病毒学重点实验室,上海 200032

收稿日期: 2021-01-04

  网络出版日期: 2021-04-25

基金资助

国家自然科学基金(31600644)

Research progress on Elizabethkingia meningoseptica and infection

  • LU Yikai1 ,
  • YUAN Shuying1 ,
  • YANG Yuanbo1 ,
  • WU Qile1 ,
  • FANG Zixuan1 ,
  • LIU Yan1 ,
  • CHEN Li2 ,
  • SUN Guiqin1
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  • 1. School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China; 2. Department of Medical Microbiology and Parasitology, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

Received date: 2021-01-04

  Online published: 2021-04-25

摘要

脑膜炎败血伊丽莎白菌(Elizabethkingia meningoseptica, EM)是一种非发酵革兰氏阴性杆菌,为医院感染的重要病原菌之一,近年来其检出率呈上升趋势。EM易感人群主要为有基础疾病、免疫功能低下或缺陷、长期使用抗生素及有侵入性操作等的患者,可引起脑膜炎、菌血症、肺部感染、眼部感染等,其多重耐药性给临床治疗带来了严峻挑战。EM除感染人类,还可感染蛙、鱼、龟、猪、犬类等动物。本文从EM的生物学特性、引发的感染类型、检测方法、感染危险因素等方面进行综述,以期对其有较全面的、新的认识,从而加强临床对其分离及检测的重视,为医院感染的预防与控制提供参考。

本文引用格式

陆怡凯1 , 袁舒颖1 , 杨源博1 , 巫祺乐1 , 方子璇1 , 刘岩1 , 陈力2 , 孙桂芹1 . 脑膜炎败血伊丽莎白菌及其感染的研究进展[J]. 微生物与感染, 2021 , 16(2) : 110 -116 . DOI: 10.3969/j.issn.1673-6184.2021.02.006

Abstract

Elizabethkingia meningoseptica (EM), a non-fermented Gram-negative bacterium, is one of the most important pathogens of nosocomial infection. The detection rate has been on the rise in recent years. The susceptible people mainly include the patients with basic diseases, immunodeficiency or deficiency, long-term use of antibiotics, invasive procedures, and so on. EM could cause meningitis, bacteremia, lung infections, eye infections, etc. Its multi-drug resistance has burdened the clinical treatment. Animals could also be infected by EM, like frogs, fish, turtles, pigs, dogs and others. The biological characteristics, infection types, detection methods and risk factors are analyzed in the present paper, which would offer a new insight of EM. Hospitals should focus on the detection, drug resistance and pathogenesis of EM, which would provide the reference for prevention and control of nosocomial infection.
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