Abstract：Abstract： To explore the characteristics and etiological factor in suspected measles cases in Shanghai city, to analyze the characteristics of suspected measles cases in Shanghai from 2014 to 2019. Pharyngeal swab specimens were collected and screened to detect 11 rash fever associated virus, including varicella-zoster virus, human parvovirus B19, HSV-1, HHV-6, HHV-7, EB virus and other enteroviruses by PCR technology. A total of 8552 pharyngeal swabs and 3325 negative pharyngeal swabs were collected from suspected measles cases from 2014 to 2019. The virus detection rate was 9.7% (108/1197). A total of 9 viruses were detected, and no mixed infection was detected. The highest positive rate of human Epstein-Barr virus was 1.8%, followed by human herpes virus type 6 (1.7%), varicella-zoster virus and human parvovirus B19 (1.3% each). The positive rate of other EV was 0.8% in 10 cases. CA6 was found in 7 cases with a positive rate of 0.6%. CA10 was found in 7 cases with a positive rate of 0.6%. HSV-1 was found in 6 cases, positive rate 0.5%; 4 cases were CA16, the positive rate was 0.3%. HSV-1 and VZV were mainly detected in children, EB, HHV-6, CA16 and CA6 were detected in adults and children at similar rates, and B19 and other enteroviruses were mainly detected in adult cases. VZV, EB and HHV6 were mainly detected in males, and HSV-1 was mainly detected in females. In addition to measles and rubella, 9 viruses including Epstein Barr virus, human herpes virus and parvovirus B19, may cause fever and rash symptoms and be clinically diagnosed as measles. More attention should be paid in clinical diagnosis. Key words： measles; suspected cases; rash and fever illness; pathogenic spectrum; PCR
崔晓娴. 上海市2014-2019年麻疹疑似病例实验室监测及病原学特征[J]. 微生物与感染, 2024, 19(1): 46-51.
Xiao-Xian CUI. Characteristics and etiological analysis in suspected measles cases in Shanghai from 2014 to 2019. JOURNAL OF MICROBES AND INFECTIONS, 2024, 19(1): 46-51.
