Abstract:Pretomanid (PA-824) is one of the latest drugs approved for the treatment of tuberculosis. Pharmacological and clinical studies have shown that regiments containing pretomanid has magnificent bactericidal activity and efficacy against both Ds-TB and Dr-TB. It’s expected that pretomanid will revolutionize TB treatment strategies when put into the clinical practice. This article reviews the pharmacological characteristics and clinical studies of pretomanid and summarizes its efficacy and safety.