Risk factors, clinical features and drug resistance analysis of nosocomial infection caused by Elizabethkingia meningoseptica in elderly patients
ZHANG Dan2，SUN Guiqin1
1. School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China; 2. Shaoxing People’s Hospital, Shaoxing Hospital, Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Abstract：This study explored the risk factors, clinical characteristics, and drug resistance of Elizabethkingia meningoseptica (EM) infection in elderly patients to provide the reference for scientific and effective clinical treatment. Analysis of 27 strains isolated from EM infected patients aged over 60 years of Shaoxing People’s Hospital from January 2018 to January 2023 was carried out using VITEK-2 automatic microbial identification and drug sensitivity analyzer for bacterial identification and drug sensitivity tests, and analyzed the clinical characteristics and drug resistance of the bacteria.EM mainly infected the patients with long hospitalization stays (hospital days ≥4 weeks), accounting for 66.7%; And patients with serious underlying diseases, including respiratory system diseases account for 44.4%, and malignant tumors 22.2%; Elderly patients who have used broad-spectrum antibacterial drugs for a long time and have undergone invasive procedures. The main type of specimen was sputum 85.2%, followed by urine of 11.1%. The patients mainly came from the department of critical care (74.1%), followed by the department of radiotherapy (7.4%). EM exhibited high resistance to a variety of broad-spectrum antibacterial drugs, but was 100% sensitive to doxycycline. Resistance to cefoperazone/tazobactam, piperacillin/tazobactam, compound sulfamethoxazole and levofloxacin was under 30%. The presence of serious underlying diseases and prolonged hospitalization, combined use of broad-spectrum antibiotics, and multiple invasive diagnoses and treatments are risk factors for elderly patients with EM infection. The phenomenon of multiple drug resistance in EM is serious. So, rational use of antibiotics, active treatment of primary diseases, minimizing invasive procedures, reducing hospital stay, and strengthening medical environmental management are conducive to the treatment and prevention of EM.
张丹2，孙桂芹1. 脑膜炎败血伊丽莎白菌致老年患者医院感染的危险因素、临床特征及耐药性分析[J]. 微生物与感染, 2023, 18(5): 278-283.
ZHANG Dan2，SUN Guiqin1. Risk factors, clinical features and drug resistance analysis of nosocomial infection caused by Elizabethkingia meningoseptica in elderly patients. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(5): 278-283.
2023, Vol. 18 
