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微生物与感染
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慢性乙型肝炎重叠急性戊型肝炎患者血清肿瘤坏死因子α和白细胞介素6的检测及其意义
赵守松;陈子安;张莉
蚌埠医学院第一附属医院感染科,蚌埠 233004
Detection and significance of serum tumor necrosis factor-α and interleukin-6 in chronic hepatitis B patients superinfected with acute hepatitis E
ZHAO Shou-Song;CHEN Zi-An;ZHANG Li
Department of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
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摘要: 本文旨在探讨肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)在慢性乙型肝炎重叠急性戊型肝炎病情加重中的作用和临床意义。采用酶联免疫吸附试验(ELISA)测定慢性乙型肝炎重叠急性戊型肝炎患者(30例)和慢性乙型肝炎患者(20例)、急性戊型肝炎患者(20例)、健康体检者(20例)的血清TNF-α、IL-6,同时检测慢性乙型肝炎重叠急性戊型肝炎、慢性乙型肝炎和急性戊型肝炎患者的主要生化指标。结果显示,与慢性乙型肝炎患者、急性戊型肝炎患者、健康体检者相比,慢性乙型肝炎重叠急性戊型肝炎患者的血清TNF-α、IL-6水平显著升高(P<0.01);与慢性乙型肝炎、急性戊型肝炎患者相比,慢性乙型肝炎重叠急性戊型肝炎患者主要生化指标丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、血清胆红素(TBIL)显著升高(P<0.05),胆固醇酯(CHE)、血浆白蛋白(ALB)、血清凝血酶原活动度(PTA)显著降低(P<0.05);慢性乙型肝炎重叠急性戊型肝炎患者的血清TNF-α、IL-6升高水平与ALT、TBIL、PTA升高或降低水平呈直线相关关系(P<0.05)。结果提示,TNF-α、IL-6参与慢性乙型肝炎重叠急性戊型肝炎免疫病理损伤过程,检测血清TNF-α、IL-6对判断慢性乙型肝炎重叠急性戊型肝炎患者肝损伤程度及预后有一定价值。
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赵守松
陈子安
张莉
关键词 重叠急性戊型肝炎肿瘤坏死因子α白细胞介素6    
Abstract

The present study was aimed to discuss the role and clinical significance of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the deterioration of chronic hepatitis B patients superinfected with acute hepatitis E. Serum TNF-α and IL-6 in chronic hepatitis B patients superinfected with acute hepatitis E (n=30), chronic hepatitis B patients (n=20), acute hepatitis E patients(n=20), and healthy volunteers (n=20) were detected by enzyme-linked immunosorbent assay (ELISA). Main biochemical quantitative analyses of serum levels of alanine aminotransferase (ALT), aspartamine transferase (AST) and total bilirubin (TBIL), cholesterol ester (CHE), albumin (ALB),and prothrombin activity (PTA) were detected by automatic biochemical analyzer. Compared to that of chronic hepatitis B patients, acute hepatitis E patients, and healthy volunteers, the serum levels of TNF-α and IL-6 in chronic hepatitis B patients superinfected with acute hepatitis E were significantly increased (P <0.01). Compared to that of chronic hepatitis B patients and acute hepatitis E patients, the serum levels of ALT, AST and TBIL in chronic hepatitis B patients superinfected with acute hepatitis E were significantly increased (P <0.05), the serum levels of CHE, ALB and PTA reduced obviously (P <0.05). The serum levels of TNF-α and IL-6 in chronic hepatitis B patients superinfected with acute hepatitis E showed a significant positive correlation with ALT and TBIL and a significant negative correlation with PTA (P <0.05). TNF-α and IL-6 participate in the process of immune injury in chronic hepatitis B patients superinfected with acute hepatitis E. Detection of the serum levels of TNF-α and IL-6 has practical clinical value in determining the degree of liver injury and prognosis of chronic hepatitis B patients superinfected with acute hepatitis E.

Key wordsChronic hepatitis B    Superinfection    Acute hepatitis E    Tumor necrosis factor-α    Interleukin-6
通讯作者: 赵守松   
引用本文:   
赵守松;陈子安;张莉. 慢性乙型肝炎重叠急性戊型肝炎患者血清肿瘤坏死因子α和白细胞介素6的检测及其意义[J]. 微生物与感染 , 2009, 4(2): 88-91 .
ZHAO Shou-Song;CHEN Zi-An;ZHANG Li. Detection and significance of serum tumor necrosis factor-α and interleukin-6 in chronic hepatitis B patients superinfected with acute hepatitis E. Journal of Microbes and Infections, 2009, 4(2): 88-91 .
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http://jmi.fudan.edu.cn/CN/      或     http://jmi.fudan.edu.cn/CN/Y2009/V4/I2/88

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