丙型肝炎是由丙型肝炎病毒（HCV）感染引起的重要传染病，有效的治疗性和预防性疫苗目前均尚未研制成功。HCV的高变异性及多种免疫逃避途径是疫苗研制的主要障碍。目前，已有多种类型的HCV候选疫苗进入临床试验或临床前期试验阶段，但其有效性、安全性等还不能令人满意。随着对HCV相关免疫应答机制的深入了解，有望研制出相应的治疗性和预防性疫苗。

Hepatitis C, caused by hepatitis C virus (HCV), is an important infectious disease。 Unfortunately，no effective vaccines are available now for the high variability of HCV and various viral evasions as the major obstacles. Candidate vaccine are being tested in clinical trails for safety and efficacy. . The research and development stages of HCV vaccine are reviewed in the present paper.