The oncogenic potential of human cytomegalovirus in breast cancer
GONG Yaya1，ZHAO Jun2，WANG Mingli2
1. The First Clinical Medical College of Anhui Medical University, Hefei 230032, China; 2. Department of Microbiology, Anhui Medical University, Hefei 230032, China
Abstract：Human cytomegalovirus (HCMV) is a common human pathogen infecting more than 70% of the world’s population. The virus has developed mechanisms to evade the host’s immune systems and it usually remains latent in its host. The expressed HCMV proteins have the potential to interfere with cell metabolism and promote the development of tumors. The detection rate of HCMV is relatively high in both nonneoplastic and neoplastic breast epithelium in patients with breast cancer. Meanwhile, published studies indicate that exposure to the virus in later development stages can cause breast cancer. Recent progress on new antiHCMV targeted therapy for breast cancer also indicates that HCMV is likely involved in the progression of breast cancer. In this review, we will discuss the oncogenic potential of HCMV and the potential association of HCMV with the initiation and progression of breast cancer.
宫亚娅1，赵俊2，王明丽2. 人巨细胞病毒感染与乳腺癌关系的研究进展[J]. 微生物与感染, 2016, 11(1): 55-58.
GONG Yaya1，ZHAO Jun2，WANG Mingli2. The oncogenic potential of human cytomegalovirus in breast cancer. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(1): 55-58.
