Abstract：Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper control of gene expression. AU-rich element RNAbinding factor 1 (AUF1) exhibits the characteristics of a transacting factor contributing to the rapid turnover of many cellular mRNAs. AUF1 controls the process of inflammation by mediating inflammatory cytokines and their responses. Studies show that AUF1 binds the internal ribosome entry site (IRES) of enterovirus 71 (EV71) and interacts with IRES to negatively regulate viral translation and replication. AUF1 could be recruited to the stress granules induced by coxsackievirus B3 and enterovirus 71.
段淳槟，王天楹，钟照华. AUF1在病毒感染及相关炎症反应中的调控作用[J]. 微生物与感染, 2016, 11(1): 44-47.
DUAN Chunbin, YANG Tianying, ZHONG Zhaohua. Role of AUF1 in viral infection and related inflammation. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(1): 44-47.