Advances in intracellular DNA sensors of PYHIN family and mechanisms of viral evasion of innate immune responses
WEI Wei1, WANG Sufei1, NI Ming2, YU Bing1
1. Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China；2. Department of Infectious Diseases, Tongji Hospital of Huazhong University of Science and Technology, Wuhan 430030, China
Abstract：The intracellular DNA sensors in host cells recognize viral nucleic acid and activate the innate immunity, then resulting in antiviral effects. However, the viral pathogens have also evolved with appropriate strategies to evade or suppress the innate immune responses. In this review, the characteristics and molecular mechanisms of the immune effects of PYHIN family, one of the DNA sensors in host cells that could recognize viral DNA and activate innate immunity are discussed. The strategies of how viruses escape from the immune surveillance are also summarized.
魏巍1，汪速飞1，倪明2，余冰1. DNA识别受体PYHIN家族及相关病毒免疫逃逸机制的研究[J]. 微生物与感染, 2016, 11(4): 252-256.
WEI Wei1, WANG Sufei1, NI Ming2, YU Bing1. Advances in intracellular DNA sensors of PYHIN family and mechanisms of viral evasion of innate immune responses. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(4): 252-256.
2016, Vol. 11 
