Abstract：The blood-brain barrier (BBB) is an important protective structure to maintain the homeostasis of the central nervous system, limiting the invasion of most pathogens in the blood. Some viruses can cross the BBB to invade the central nervous system by cellular and (or) paracellular ways, causing neurological dysfunction. The cellular ways consist of direct infection of the brain microvascular endothelial cells and transcellular pathway. The paracellular ways are composed of breaching of the tight junction between endothelial cells and the “Trojan horse” pathway. In this review, the current research progress on viral impacts on the BBB is summarized.
朱耐伟，朱勇喆，戚中田. 病毒穿越血脑屏障的两种方式与可能机制[J]. 微生物与感染, 2016, 11(6): 366-373.
ZHU Naiwei, ZHU Yongzhe, QI Zhongtian. Two ways and possible mechanisms of virus crossing the blood-brain barrier. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(6): 366-373.