2019冠状病毒病(coronavirus disease 2019，COVID-19)是由严重急性呼吸综合征冠状病毒2 (severe acute respiratory syndrome coronavirus 2，SARS-CoV-2)导致的感染性疾病。SARS-CoV-2感染人体后除作用于肺部的SARS-CoV-2功能受体外，还可以作用于心脏、消化道、肝脏、肾脏、中枢系统的SARS-CoV-2功能受体，引起肺外脏器的损伤，诱发多器官功能衰竭，增加COVID-19的病死率。但目前对SARS-CoV-2引起肺外各脏器损伤的具体作用机制还不是很清楚，需要更多临床和实验室数据支持。通过检索COVID-19相关的文献，对SARS-CoV-2导致的肺外系统影响及其可能作用机制作一综述。

Coronavirus disease 19 (COVID-19) related studies that were published on journals and medRxiv were reviewed to explore effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on extrapulmonary organs and its potential mechanisms. In addition to respiratory organs, the expression of SARS-CoV-2 functional receptor has also been observed in human hearts, gut, liver, kidneys, and central nervous systems. The action of SARS-CoV-2 on extrapulmonary receptors may contribute to multiple organ dysfunction and the high mortality rate of COVID-19. However, the exact mechanism leading to extrapulmonary impairments in COVID-19 patients remains elusive and further research is needed to provide more evidence.