Utilization of the ubiquitin system by viruses for survival and
propagation
XIONG Yao1; LIU Hong-Xia2; HUANG Qiao-Bing2
1 . First Clinical College of Medicine, Southern Medical University, Guangzhou 510515, China; 2 . School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Abstract：As a complicated systemin eukaryocytes, the ubiquitin systemincludes mainly ubiquitin, 26S proteasome, enzyme E1, enzyme E2 , andenzyme E3. The ubiquitin-proteasome pathway is a major intracellular systemfor extralysosomal protein degradation and plays an important role in various cellular functional regulations. It has been found that many viruses could utilize the ubiquitin systemf or their own survival and reproduction by down-regulating surface immune molecules to escape the host immune responses, regulating viral transcription, inhibiting cellular apoptosis and helping with viral budding and release. Exploring the mechanisms underlying the use of the ubiquitin systemby viruses may provide an alternate view to understand the infection mechanisms and provide new targets for related antiviral therapeutics.
熊瑶1; 刘红霞2; 黄巧冰2 . 病毒利用泛素系统生存、增殖的方式[J]. 微生物与感染
, 2010, 5(1): 61-64 .
XIONG Yao1; LIU Hong-Xia2; HUANG Qiao-Bing2. Utilization of the ubiquitin system by viruses for survival and
propagation. Journal of Microbes and Infections, 2010, 5(1): 61-64 .
2010, Vol. 5 
