SARS-CoV-2细胞受体的研究进展

陈生林1*,肖蔓2 *,李赵忠3,徐志凯1,韩起1,冯东方1,邓雁1,殷作明1

微生物与感染 ›› 2023, Vol. 18 ›› Issue (1) : 46-54.

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微生物与感染 ›› 2023, Vol. 18 ›› Issue (1) : 46-54. DOI: 10.3969/j.issn.1673-6184.2023.01.006
综述

SARS-CoV-2细胞受体的研究进展

  • 陈生林1*,肖蔓2 *,李赵忠3,徐志凯1,韩起1,冯东方1,邓雁1,殷作明1
作者信息 +

Recent progress on cell receptors for SARS-CoV-2

  • CHEN Shenglin1*, XIAO Man2*, LI Zhaozhong3, XU Zhikai1, HAN Qi1, FENG Dongfang1, DENG Yan1, YIN Zuoming1
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摘要

严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)是引起2019冠状病毒病(coronavirus disease 2019,COVID-19)的病原体,在人群中广泛持久传播,对人类健康和社会经济造成了巨大危害。目前,针对COVID-19的治疗尚无特异高效的抗病毒药物。病毒为实现寄生感染,通常先与宿主细胞膜表面受体结合,进而内化入胞。因此,SARS-CoV-2受体决定着病毒的感染特性和宿主范围,对其进行研究和解析是战胜SARS-CoV-2感染的一个关键手段。SARS-CoV-2受体的发现和鉴定,将为COVID-19提供新的治疗靶点。本文主要对SARS-CoV-2入侵受体及黏附受体的研究进展进行综述。

Abstract

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the coronavirus disease 2019(COVID-19), which spreads rapidly in humans and endangers global health and economy. There are no specific and effective antiviral drugs for the treatment of COVID-19 currently. To infect host cells successfully for a virus, receptor binding and virus internalization are considered to be the initial steps. A key to combat SARS-CoV-2 infection is to investigate the viral receptors, which determine its infectivity and host range. The discovery and identification of cell receptors for SARS-CoV-2 will provide new therapeutic targets for COVID-19. This article reviews the recent findings on the entry and attachment receptors for SARS-CoV-2.

关键词

严重急性呼吸综合征冠状病毒2 / 入侵 / 受体 / 黏附受体 / 刺突蛋白 / 受体结合域

Key words

Severe acute respiratory syndrome coronavirus 2 / Entry / Receptor / Attachment receptor / Spike / Receptor-binding domain

引用本文

导出引用
陈生林1*,肖蔓2 *,李赵忠3,徐志凯1,韩起1,冯东方1,邓雁1,殷作明1. SARS-CoV-2细胞受体的研究进展[J]. 微生物与感染. 2023, 18(1): 46-54 https://doi.org/10.3969/j.issn.1673-6184.2023.01.006
CHEN Shenglin1*, XIAO Man2*, LI Zhaozhong3, XU Zhikai1, HAN Qi1, FENG Dongfang1, DENG Yan1, YIN Zuoming1. Recent progress on cell receptors for SARS-CoV-2[J]. Journal of Microbes and Infections. 2023, 18(1): 46-54 https://doi.org/10.3969/j.issn.1673-6184.2023.01.006
中图分类号: R373.1   

基金

军队重点课题(BLB18J008)

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