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| Molecular basis and clinical application of hepatitis B core-related antigen |
| ZHANG Shenyan*，SHEN Zhongliang*，ZHANG Jiming |
| Department of Infectious Diseases of Huashan Hospital, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Fudan University, Shanghai 200040, China |
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Abstract As a recently discovered serological marker, hepatitis B core-related antigen (HBcrAg) consists of hepatitis B core antigen (HBcAg), hepatitis B e antigen (HBeAg) and p22cr. Serum HBcrAg can reflect the level and transcriptional activity of intrahepatic covalently closed circular DNA, as well as predict the natural history of patients with chronic hepatitis B or the efficacy and prognosis of nucleos(t)ide analogues and interferons, including the incidence of clinical outcomes such as relapse and functional cure, thus providing guidance for the determination of the starting point and endpoint of clinical antiviral therapy and the selection of treatment regimens. HBcrAg levels are also associated with the incidence of HBV-associated hepatocellular carcinoma(HCC), which can identify potential high-risk patients for HCC. Therefore, HBcrAg has important clinical application value in the diagnosis and treatment of chronic hepatitis B.
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Received: 22 May 2022
Published: 25 February 2023
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Corresponding Authors:
ZHANG Jiming
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2023, Vol. 18 
