|
|
|
| Research progress on gene-edited intestinal bacteria in the treatment of colorectal cancer |
| LIU Yincong1, 2, ZHANG Yuting2, WANG Yilan2, LIU Min2, WANG Wenxue2, GENG Jiawei2 |
| 1. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China; 2. Department of Infectious Diseases and Liver Diseases, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China |
|
|
|
|
Abstract Colorectal cancer (CRC) is a common digestive malignant tumor in China. A large number of studies have confirmed that intestinal flora disorders can promote the occurrence and development of CRC through a variety of mechanisms, and regulating intestinal flora can exert certain auxiliary therapeutic effects on CRC. But the treatment still has certain limitations and side effects. Studies have shown that the clinical treatment of CRC by engineered and edited intestinal bacteria through gene editing may have potential application values. In this paper, the current research progress on gene-editing for modifying intestinal bacteria in the treatment of CRC is reviewed, aiming to explore the possibility of gene-edited intestinal bacteria in the treatment of CRC in the future.
|
|
Received: 03 August 2022
Published: 25 April 2023
|
|
|
|
Corresponding Authors:
WANG Wenxue，GENG Jiawei
|
|
|
|
|
|
|
2023, Vol. 18 
