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::: Office ::: Online Submission Manuscript Tracking Peer Review Editor Work Office Work Editor-in-chief   ::: Journal ::: Forthcoming Articles Current Issue Next Issue Archive Email Alert   Read Articles Download Articles   Quick Search       Advanced Search         2023 Vol.18 No.3 Published 2023-06-25 ) [HTML 1KB] [PDF 0KB] ( 3 ) 137 Development of national reference for Yersinia pestis F1 antibody detection reagents To prepare a national reference for detection reagents of Yersinia pestis F1 antibody, which was consisted of six positive references, eight negative references, one minimum detection limit reference and one repetitive reference. The uniformity and stability of this reference met the requirements for national reference. The collaborative calibrated results of 4 laboratories showed that six positive references were 100% positive, eight negative references were 100% negative, the detection level of the minimum detection limit reference was between the original solution to 100 times diluted solution, repetitive reference test results were consistent（For Enzyme-linked immunosorbent assay and up-trans-luminescence detection reagent, the CV of test results of reference for precision was no more than 15%. National reference for detection reagents of Yersinia pestis F1 antibody was prepared which was suitable for the quality evaluation and control of related reagents. 2023 Vol. 18 (3): 137-142 [Abstract] ( 5 ) [HTML 1KB] [PDF 0KB] ( 5 ) 143 Analysis of distribution and antimicrobial resistance of pathogenic bacteria in 1396 patients' blood cultures in a tertiary first-class hospital in Shanghai during 2014-2021 To provide reference for rational use of antibiotics in clinic, we investigate the distribution and antimicrobial resistance of pathogens causing bloodstream infection. The main pathogenic bacteria isolated from positive blood culture specimens and their antimicrobial resistance in our hospital from 2014 to 2021 were statistically analyzed. After eliminating the duplicate strains, a total of 1396 strains of pathogenic bacteria were detected in blood culture samples during the past eight years. The gram-negative bacteria, gram-positive bacteria and fungi account for 56.3%, 38.4% and 5.3%, respectively. The top eight strains were Escherichia coli accounting for 21.5% (300/1396), Coagulase negative Staphylococcus (CNS) accounting for 17.4% (243/1396), Klebsiella pneumoniae accounting for 14.9% (208/1396), Staphylococcus aureus accounting for 7.2% (100/1396), Acinetobacter baumannii accounting for 5.4% (76/1396), Enterococcus faecalis accounting for 4.2% (58/1396), Enterococcus faecium accounting for 3.7% (51/1396) and Pseudomonas aeruginosa accounting for 3.5% (49/1396). The resistance rate of Escherichia coli to third-generation cephalosporins exceeded 50%, and the resistance rate to carbapenems was as low as 1%; The resistance rate of Klebsiella pneumoniae to carbapenems was 46.3%; The cumulative resistance rate of Acinetobacter baumannii to cephalosporins, aminoglycosides and carbapenems was more than 45%; The cumulative rates of MRSA and CNS were 44.6% and 74.5%, respectively. 2023 Vol. 18 (3): 143-150 [Abstract] ( 7 ) [HTML 1KB] [PDF 0KB] ( 5 ) 151 Analysis of intestinal microbiota in patients with major depressive disorder based on high-throughput sequencing In this study, feces from 19 cases of major depressive disorder (MDD) and 20 healthy individuals were collected for 16S rRNA high-throughput sequencing, in order to investigate the gut microbiota profile of depression and whether gut microbiota can be a predictor of depression. Participants' assessment scores for PHQ-9 and GAD-7 were analysed in relation to the difference microbiota between the two groups. No significant difference in alpha diversity in depressed compared to healthy individuals. Differential species analysis revealed a significant enrichment in the depression group for six signature microorganisms Finegoldia, Lactiaseibacillus, Enterobacterales, Enterobacteriaceae, Fusicatenilbacter, and Closteridia. Significant enrichment of Coprococcus in the healthy group was significantly and negatively correlated with levels of depression and anxiety. The structure and composition of the gut flora of patients with depression were resolved based on high-throughput sequencing of gut microbial 16SrRNA, and provided potential microbial markers for the alleviation of clinical symptoms of depression in this study. 2023 Vol. 18 (3): 151-156 [Abstract] ( 6 ) [HTML 1KB] [PDF 0KB] ( 4 ) 157 Analysis of characteristics and risk factors of infections in pemphigus We aim to analyze the characteristics of infections in pemphigus including localization and pathogen spectrum, to explore the risk factors of infections, and to provide guidance for clinical treatment and prevention. This retrospective case-control study enrolled 142 pemphigus patients hospitalized in Huashan Hospital from January 2017 to December 2021 and information including infection rate, susceptible location and pathogen distribution was collected through medical records and laboratory results. Univariate analysis and multivariate logistic regression analysis were performed to identify the risk factors of infections. 74 (52.1%) of 142 hospitalized pemphigus patients had infection. Univariate analysis of risk factors showed that infected group patients had more hypoalbuminemia (P < 0.001), used more systemic glucocorticoid treatments (P <0.001) and used higher cumulative dose of gluco-corticoids in recent 3 months (P=0.001). Multivariate logistic regression analysis showed that hypoal-buminemia (OR=7.90，95% CI 1.92-32.49) and systemic glucocorticoid treatment (OR=6.25，95% CI 2.63-14.83) were risk factors of infections in pemphigus patients. The most susceptible locations of infection were wound surface and lung, and most common pathogens were Staphylococcus aureus, Pseudomonas aeruginosa. In conclusion，hypoalbuminemia and systemic glucocorticoid treatment were risk factors of infections in pemphigus. Related measures are supposed to be taken as early as possible to prevent and control infections. 2023 Vol. 18 (3): 157-162 [Abstract] ( 6 ) [HTML 1KB] [PDF 0KB] ( 4 ) 163 A case report of disseminated Talaromycosis and literature review A 56 years old males with "sore throat" was treated in our hospital, he was once suspected lymphoma. With the progressession of disease, manifestations such as fever, cough with sticky phlegm, weakness in lifting eyelids, distortion of commissure, melena, rash and lymphadenopathy occurred. After biopsy of mediastinal lymph node and pathogen culture, he was finally diagnosed as disseminated Talaromycosis. We reviewed the literature on the pathology, clinical features, pathogenesis, and treatment options in Talaromycosis. 2023 Vol. 18 (3): 163-170 [Abstract] ( 2 ) [HTML 1KB] [PDF 0KB] ( 5 ) 171 Lingy-Yun Song Advances in pretomanid(PA-824) for tuberculosis treatment Pretomanid (PA-824) is one of the latest drugs approved for the treatment of tuberculosis. Pharmacological and clinical studies have shown that regiments containing pretomanid has magnificent bactericidal activity and efficacy against both Ds-TB and Dr-TB. It’s expected that pretomanid will revolutionize TB treatment strategies when put into the clinical practice. This article reviews the pharmacological characteristics and clinical studies of pretomanid and summarizes its efficacy and safety. 2023 Vol. 18 (3): 171-175 [Abstract] ( 6 ) [HTML 1KB] [PDF 0KB] ( 3 ) 176 Research Progress on immune regulation of non coding RNA in sepsis Sepsis is a systemic inflammatory response syndrome caused by bacterial, viral and fungal infections. This inflammatory response induced by pathogenic microorganisms can lead to the failure of multiple organ systems, resulting in serious consequences. Studies have shown that the expression of some non coding RNAs such as long-chain non coding RNA (lncRNA), microRNA (miRNA) and circular RNA (circRNA) changes during sepsis. These transcripts can participate in multiple organ system failure through different mechanisms. In this review, we describe the role of these three classes of noncoding RNAs in sepsis and its related complications. 2023 Vol. 18 (3): 176-192 [Abstract] ( 4 ) [HTML 1KB] [PDF 0KB] ( 5 ) Reader Login Author Center Online Submission Author Instruction Layout Art Copyright Agreement News More >>   Other Journal

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