摘要
利奈唑胺是一种重要的噁唑烷酮类药物, 对临床上具重要意义的革兰阳性菌, 包括多重耐药葡萄球菌、耐万古霉素肠球菌等有抗菌作用。目前虽然细菌耐利奈唑胺的情况并不严重, 但临床耐药株的出现值得关注。本文综述了细菌对利奈唑胺的耐药机制及检测方法。其耐药机制主要由细菌单个碱基突变和甲基转移酶的产生所介导, 还有一些耐药机制尚不明了。检测方法主要有微生物学和分子生物学方法, 部分方法尚需进一步完善。
Abstract
Linezolid is an antibacterial belonging to the oxazolidinone class of antibiotics. The importance of linezolid as an antibiotic is related to its activity against a number of clinically significant Gram-positive cocci, including multidrug-resistant staphylococci and vancomycin-resistant enterococci. Although bacterial resistance to linezolid is not a major issue at present, its development in clinical isolates should be paid more attention. In this article, the mechanisms of bacterial resistance to linezolid, and related detection methods were reviewed. We showed that bacterial resistance is mediated by a single-nucleotide mutation and the production of methyltransferase, however, other potential mechanisms have not yet been determined. The detection methods for linezolid resistance include microbiological and molecular biological methods, some of which would benefit fromtechnological improvements.
关键词
耐药 /
噁唑烷酮 /
细菌
Key words
Linezolid /
Resistance /
Oxazolidinone /
Bacteria
夏梦岩1 ；张卓然2.
细菌对利奈唑胺的耐药机制及检测方法研究进展[J]. 微生物与感染. 2009, 4(3): 170-173
XIA Meng-Yan1；ZHANG Zhuo-Ran2.
Advances in mechanisms of bacterial resistance to linezolid and
related detectionmethods[J]. Journal of Microbes and Infections. 2009, 4(3): 170-173
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
PDF(79 KB)
