新生隐球菌( Cn) 是临床上重要的病原真菌, 树突细胞( DC) 则是最重要的抗原呈递细胞。作为宿主固有免疫和适应性免疫的联系枢纽,DC 对于识别病原、呈递抗原、诱导宿主免疫应答十分重要。许多研究证明,DC 可通过细胞表面的多种受体有效识别新生隐球菌抗原( CnAg) , 诱导宿主产生有效的细胞免疫应答。DC 本身也有一定的杀菌能力, 但DC 的不同亚群以及成熟状态对宿主的免疫防御功能有重要影响。另外, 隐球菌除具有甘露糖蛋白等主要免疫显性抗原外, 还有多种抑制机体保护性免疫应答的毒性因子。本文就近年来国内、外对两者之间复杂机制的研究进行概述。

Cryptococcus neoformans is an important fungal pathogen in clinical practice. Dendritic cells (DCs) are the most powerful antigen-presenting cells , which function as the central link between innate and adaptive
immune responses. They are important in recognizing a variety of pathogens, presenting antigens, and inducing immune responses. Many investigations demonstrate that DCs can effectively recognize cryptococcal antigens through several receptors on the cellular surface and promote valid cell-mediated immune responses against invasive microbes. Meanwhile, DCs themselves have shown a certain capacity to kill Cryptococcus neoformans ; however , subset type or the maturation status of DCs can significantly affect the host immune defense . On the other hand, Cryptococcus neoformans has some virulence factors, which can inhibit the induction of protective immune responses, although mannoproteins have been identified as the main immunodominant antigens in Cryptococcus neoformans . In this article , the complicated mechanisms of interplay between DCs and Cryptococcus neoformans in recent years are reviewed.