真核生物中, 泛素系统是个复杂的体系, 主要包括泛素,26S 蛋白酶体和酶系统E1、E2 、E3。泛素- 蛋白酶体通路是细胞内非溶酶体蛋白降解的主要系统, 在许多细胞功能中发挥重要作用。最近研究发现, 许多病毒利用泛素系统为其自身服务, 这涉及病毒生活史的各个阶段并干扰宿主抗病毒反应的多种方式, 如下调细胞表面免疫分子而实现免疫逃避、调控病毒的基因转录、抑制细胞凋亡、促使病毒出芽和释放等。深入了
解病毒利用泛素系统的机制, 将为研究病毒感染机制提供新的视角, 并为药物研发提供新的靶标。

As a complicated systemin eukaryocytes, the ubiquitin systemincludes mainly ubiquitin, 26S proteasome, enzyme E1, enzyme E2 , andenzyme E3. The ubiquitin-proteasome pathway is a major intracellular systemfor extralysosomal protein degradation and plays an important role in various cellular functional regulations. It has been found that many viruses could utilize the ubiquitin systemf or their own survival and reproduction by down-regulating surface immune molecules to escape the host immune responses, regulating viral transcription, inhibiting cellular apoptosis and helping with viral budding and release. Exploring the mechanisms underlying the use of the ubiquitin systemby viruses may provide an alternate view to understand the infection mechanisms and provide new targets for related antiviral therapeutics.