广西地区110株热带假丝酵母感染分布与药敏分析

吴开进,陈国添

微生物与感染 ›› 2012, Vol. 7 ›› Issue (4) : 219-221.

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微生物与感染 ›› 2012, Vol. 7 ›› Issue (4) : 219-221.
论著

广西地区110株热带假丝酵母感染分布与药敏分析

  • 吴开进,陈国添
作者信息 +

A retrospective study of 110 Candida tropicalis infections in Guangxi

  • WU Kai-Jin,CHEN Guo-Tian
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摘要

本文旨在探讨热带假丝酵母感染的分布特点及其对抗真菌药物的敏感性。对分离自临床标本的热带假丝酵母,采用真菌显色培养基和法国生物梅里埃ID32C 鉴定板确认菌种, BIO-KONT酵母样真菌快速显色最低抑菌浓度(MIC)法进行体外药敏试验。结果显示,2010 年1月~2011年12月共分离热带假丝酵母110株,占假丝酵母的14.34% 。热带假丝酵母对制霉菌素、两性霉素B 和氟胞H密院敏感率均>90.00%; 对瞠类药物的敏感率为44.55%~90.00%; 对特比茶芬的敏感率仅8.18% 热带假丝酵母感染易见于呼吸道疾病、泌尿道疾病和糖尿病。制霉菌素、两性霉素B、氟胞H密院对热带假丝酵母具有较好的抗菌活性,可作为首选药物。而热带假丝酵母对以氟康瞠为代表的瞠类药物敏感率下降,对特比荼芬的耐药率较高,不适合选用此类药物。

Abstract

The present paper aims to investigate the clinical distribution of Candida tropicalis (C. tropicalis) and its sensitivity to antifungal drugs. C. tropicalis isolates were separated from clinical specimens, and defined by ID 32 C identification system of BioMerieux. BIO-KONT fungal rapid color-development method was applied to test susceptibility to antifungal drugs in vitro. From January 2010 to December 2011 a total of 110 C. tropicalis isolates were separated, accounting for 14.34 % of all isolates of Candida. The infection of C. tropicalis was common in respiratory diseases, urinary tract diseases and diabetes. Over 90.00% of the isolates were sensitive to nystatin, amphotericin B and flucytosine. Sensitivities to azoles were between 44.55%-90.00%. Only 8.18% of the isolates were sensitive to terbinafine

关键词

热带假丝酵母 / 抗真菌药物 / 药敏试验

Key words

Candida tropicalis / Antifungal drug / Drug sensitivity test

引用本文

导出引用
吴开进,陈国添. 广西地区110株热带假丝酵母感染分布与药敏分析[J]. 微生物与感染. 2012, 7(4): 219-221
WU Kai-Jin,CHEN Guo-Tian. A retrospective study of 110 Candida tropicalis infections in Guangxi[J]. Journal of Microbes and Infections. 2012, 7(4): 219-221

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