大肠埃希菌外膜蛋白酶T毒力机制的研究进展

惠长野

PDF(8547 KB)

微生物与感染 ›› 2012, Vol. 7 ›› Issue (4) : 233-238.

综述

大肠埃希菌外膜蛋白酶T毒力机制的研究进展

惠长野¹，黄胜和²，曹虹²，张艳芳¹

作者信息 +

Progresses on the virulence mechanism of outer membrane protease T from Escherichia coli

HUI Chang-Ye¹, HUANG Sheng-He², Cao Hong², Zhang Yan-Fang¹

Author information +

文章历史 +

摘要

大肠埃希菌是引发尿路感染的主要病原体。流行病学调查显示，外膜蛋白酶T(OmpT) 与尿路感染中大肠埃希菌的毒力相关。本文就OmpT的底物专一性、对宿主阳离子抗菌肤的抵抗，以及在纤溶系统和菌株茹附侵袭中的作用等方面的研究进展进行综述。

Abstract

Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections worldwide. Outer membrane protease T (OmpT) , as a putative uropathogenic virulence factor , is found more frequently in UPEC than in fecal isolates. This review covers the current progress on substrate specificity of OmpT, resistance to cationic antimicrobial peptides, roles in the fibrinolytic system and bacterial adhesion and invasion.

导出引用

惠长野1，黄胜和2，曹虹2，张艳芳1. 大肠埃希菌外膜蛋白酶T毒力机制的研究进展[J]. 微生物与感染. 2012, 7(4): 233-238

HUI Chang-Ye1, HUANG Sheng-He2, Cao Hong2, Zhang Yan-Fang1. Progresses on the virulence mechanism of outer membrane protease T from Escherichia coli[J]. Journal of Microbes and Infections. 2012, 7(4): 233-238