巨噬细胞是机体重要的免疫细胞。当沙门菌侵袭时可迅速作出反应通过多种杀伤机制杀灭病原菌;同时分泌细胞因子和趋化因子调控免疫应答，并募集活化更多的巨噬细胞、中性粒细胞和淋巴细胞，发挥抗感染作用。此外，巨噬细胞在沙门菌侵袭过程中还具有特殊功能，作为兼性胞内菌的宿主细胞帮助其播散至全身，从而造成机体感染。本文就近年来巨噬细胞在沙门菌感染过程中的作用作一综述。

Macrophages can make quick responses to Salmonella invasion. It controls infection through secreting cytokines and chemokines, and recruiting more macrophages, neutrophils and lymphocytes. In addition , macrophages could also help Salmonella to disseminate in the body and cause infection. In this paper, the different roles of macrophages play during Salmonella infection are reviewed