虽然高效抗反转录病毒治疗(HAART) 在抗人类免疫缺陷病毒(HIV) 感染中有较为卓越的疗效，但是HIV 潜伏库的存在使HIV感染者面临无法完全根除HIV的困扰。目前，对HIV潜伏库的清除研究主要集中在药物治疗或基因治疗领域本文就近年来相关领域的研究进展进行综述。

Highly active antiretroviral therapy (HAART) has driven human immunodeficiency virus (HIV) to undetectably low levels in the blood and improved life quality of HIV / acquired immunodeficiency syndrome (AIDS) patients. However, the eradication of HIV-1 is hindered by the persistence of long-lived, latently infected memory CD4 T cells and the formation of viral reservoirs. Research on HIV reservoir eradication mainly focus on gene therapy , drug treatment targeting latently HIV-1-infected cells or directly reactivating the latent viruses, which are easier to be killed by antiviral therapy. In this review , the recent research progress on HIV reservoir and its eradication is summarized.