Scirpusin A和Scirpusin B是从药用植物中发现的2种天然茋类二聚体，具有一定的抗病毒效应。本研究利用人类免疫缺陷病毒1型（HIV-1）包膜和水疱性口炎病毒G蛋白（VSV-G）包膜包被的HIV假病毒及实验室适应株HIV-1 ⅢB，在体外评价2种药物的抗病毒效果并初步探讨其作用机制。研究发现，Scirpusin A和Scirpusin B不仅能在体外有效抑制HIV假病毒感染TZM-bl细胞（一种HIV-1易感细胞），还能抑制实验室适应株HIV-1 ⅢB。Scirpusin B的作用优于Scirpusin A，对实验室适应株HIV-1 ⅢB，Scirpusin B的半抑制浓度（IC50）为1.33 μmol/L，Scirpusin A的IC50为4 .77 μmol/L。此外，Scirpusin A和Scirpusin B还能抑制VSVG-HIV，提示其作用可能与病毒在细胞内的复制过程相关。Scirpusin A在病毒进入细胞后仍可发挥抑制作用，但具体机制尚待深入研究。

Scirpusin A and Scirpusin B, two stilbene dimmers purified from medicinal plants, showed potent anti-viral activity. In this study, human immunodeficiency virus (HIV) envelope and vesicular stomatitis virus G protein (VSV-G)-pseudotyped HIV-1 as well as laboratory-adapted HIV-1 strain IIIB were used to evaluate the effects of these two compounds against HIV-1 in vitro. The results indicated that Scirpusin A and Scirpusin B prevented infection of TZM-bl cell line (susceptible to HIV-1 infection) by pseudotyped HIV-1 and laboratory strain IIIB in vitro. Scirpusin B showed a little higher activity than Scirpusin A. The 50% inhibitory concentration (IC50) of the latter was 1.33 μmol/L while the IC50 of the former was 4.77 μmol/L. Scirpusin A and Scirpusin B also showed similar effects on inhibiting VSV-G pseudotyped HIV-1 in TZM-bl cells, suggesting these two compounds can affect the cellular replication process of HIV-1. The preliminary study indicates that Scirpusin A could play antiviral roles after virus entering cell. The detailed mechanism is still a long way to go.