乙型肝炎病毒（HBV）感染是威胁全球特别是我国人民健康的重大问题。动物模型是研究HBV生物学特性、感染机制、与宿主相互关系及筛选治疗性药物和疫苗的重要工具。近年来，各种动物模型的发展促进了HBV相关研究，但现有模型均存在一定弊端。经济、适用且与人类感染极度相似的动物模型的缺乏严重制约着人们对HBV的深入研究。本文就已有HBV动物模型进行综述，以期为更好模型的建立提供帮助。

Hepatitis B virus (HBV) infection is a major health problem in the world, especially in China. Animal model is an important tool for studying HBV biological characteristics, pathogenesis of infection, virus-host interplay, screening of novel therapeutic targets and so on. In recent years, the development of various animal models accelerates HBV-related researches, however, all the existing models have their own disadvantages. Lacking of economical and applicable animal models that could imitate the natural course of human infection has seriously restricted the further study of HBV. This paper summarizes the current HBV animal models, which could provide the help for generation of ideal animal models.