分析深圳市南山区人民医院粪肠球菌感染患者的临床资料，探讨引起感染的危险因素，为防治耐利奈唑胺粪肠球菌感染提供临床参考。选取2010年1月—2015年9月在深圳市南山区人民医院住院的165例粪肠球菌感染患者，根据药敏结果分为利奈唑胺敏感组(103例)和利奈唑胺中介/耐药组(62例)。165例粪肠球菌主要来源于中段尿培养，占53.94%，其次为伤口分泌物培养(21.82%)、血培养(6.06%)；科室分布以泌尿外科和肝胆外科为主，分别占35.76%和9.70%。单因素分析显示，碳青霉烯类抗生素暴露、留置尿管与感染相关。Logistic回归分析进一步明确碳青霉烯类抗生素暴露、留置尿管为耐利奈唑胺粪肠球菌感染的危险因素，提示应严格掌握碳青霉烯类抗生素的适应证，加强医院内感染的控制管理。

To analyze the risk factors of infections caused by linezolid-resistant Enterococcus faecalis (E. faecalis), 165 cases from Shenzhen Nanshan District People’s Hospital with E. faecalis infection recorded from January 2010 to September 2015 were studied. The patients were divided into linezolid-sensitive group and linezolid-resistant/intermediate group. E. faecalis mainly came from urine culture (53.94%), and then wound secretion culture (21.82%) and bloodstream culture (6.06%). E. faecalis infection was mainly found in Department of Urology (35.76%) and Department of Hepatobiliary Surgery (9.70%). Both univariate analysis and logistic regression analysis showed that carbapenem exposure and indwelling catheter were associated with linezolid-resistant E. faecalis infections. The results suggest that the clinical application of carbapenems should be strictly controlled, and the management of nosocomial infection should be strengthened.