目的 建立一整套可参考、可复制的精准感控技术规范化管理体系，为促进医院抗菌药物合理应用、遏制细菌耐药提供借鉴。方法 以微生物监测管理体系、抗菌药物合理应用管理体系的构建为抓手，以专业人才培养为载体，形成并不断优化基于院感、医务、临床、药学、检验、护理等多部门联动的精准管理策略。对我院2017年1月-2022年12月微生物送检、多重耐药菌检出情况以及抗菌药物合理使用相关指标等进行回顾性分析，评价该体系的实施效果。结果 构建并逐步完善了多部门联动精准感控管理体系，2019-2022年较2017年-2019年相比，住院治疗用抗菌药物使用前送检率由61.32%升高至64.17%，医院多重耐药菌MRSA、CRKPN、CRAB、CRPA）感染率明显下降；患者住院期间抗菌药物使用强度由43.32（2018年）降至40.39（2022年）。结论 本研究提出的基于精准感控的多部门联动管理体系，能有效促进抗菌药物合理应用和遏制细菌耐药，该体系可作为医院感控部门的参考，在医疗机构内推广复制。

Objective To propose a set of referable and replicable standardized management system of sensory control technology, so as to provide reference for promoting the rational application of antibiotics in hospitals and curbing bacterial drug resistance. Methods With the establishment of a microbiological monitoring management system and rational application management system of antibiotics as the starting point and the cultivation of professional talents as the carrier, the management strategy based on the linkage of hospital sense, medical, clinical, pharmaceutical, laboratory and nursing departments was formed and continuously optimized. The detection situations of multi-drug resistant bacteria, occurrence of nosocomial infection, relevant indicators of rational use of antibiotics in our hospital from January 2018 to December 2022 were retrospectively analyzed to evaluate the implementation effect of this strategy. Results In the process of constructing and gradually improving the multi-department linkage management strategy, the pre-application detection rate of inpatient antibiotics increased from 61.32% to 64.17% from 2019-2022 compared with 2017-2019, and the infection rate of multi-drug resistant bacteria MRSA, CRKPN, CRAB and CRPA in hospitals showed a significant decline. The intensity of antibiotic use during hospitalization decreased from 43.32 (2018) to 40.39 (2022). Conclusion The multi-department linkage management system based on precision infection control proposed in this study can effectively promote the rational application of antibiotics and curb bacterial drug resistance, and this system can be used as a reference for hospital infection control departments to promote and replicate in medical institutions.