本研究旨在了解上海宝山吴淞地区门诊与住院女性患者人型支原体（Mycoplasma hominis, Mh）与解脲脲原体（Ureaplasma urealyticum ,Uu）感染及药敏情况，为临床诊治工作提供科学依据。采用支原体培养鉴定计数药敏试剂盒，对患者进行支原体培养、鉴定和药敏试验。 共413例进行了支原体培养+药敏试验检测，结果显示其中165例支原体培养结果阳性（39.95 %），单纯Mh感染17例（4.12 %），单纯152感染（36.80 %），混合感染9例（2.18 %）。单纯Mh感染时，敏感率前五位由高到低依次为：强力霉素/美满霉素、交沙霉素、克林霉素、加替沙星，前三者无显著性差异（P>0.05），强力霉素/美满霉素与克林霉素、加替沙星有显著性差异（P<0.05，P<0.01）；耐药率前五位由低到高依次为：强力霉素/美满霉素、交沙霉素、加替沙星、甲砜霉素，五者无显著性差异（P>0.05）。单纯Uu感染时，敏感率前五位由高到低依次为：强力霉素/美满霉素、交沙霉素、阿奇霉素、克拉霉素，前三者差异无统计学意义（P>0.05），强力霉素/美满霉素与阿奇霉素或克拉霉素差异有统计学意义（P<0.01）；耐药率由低到高依次为：强力霉素/美满霉素、交沙霉素、加替沙星、阿奇霉素/红霉素/左氧氟沙星，强力霉素/美满霉素的耐药率与后两者差异无统计学意义（P>0.05），与阿奇霉素/红霉素/左氧氟沙星耐药率差异有统计学意义（ P<0.05）。本研究证实 本地区治疗生殖道支原体感染时，应尽量选择美满霉素、强力霉素或交沙霉素，单纯Mh和Uu感染的备选药物分别是克林霉素和阿奇霉素。

The purpose of this study is to understand the infection and drug sensitivity of Mycoplasma hominis (Mh) and Ureaplasma urealyticum (Uu) in outpatient and in Wusong District, Baoshan, Shanghai, for clinical diagnosis and treatment. Provide scientific evidence. Mycoplasma culture identification and count drug sensitivity kit were used to carry out mycoplasma culture, identification and drug sensitivity test. A total of 413 cases were tested for mycoplasma culture + drug sensitivity test, the results displayed that 165 cases were positive for mycoplasma culture (39.95%), 17 cases with simple Mh infection (4.12%), simple 152 infection (36.80%), and 9 cases of mixed infection (2.18%). In simple Mh infection, the top five sensitivity rates from high to low are: doxytetramycin/methamycin, oxytetramycin, clindamycin and gatifloxacin. There is no significant difference between the first three (P>0.05). There is a significant difference between oxytetramycin/methamycin and clindamycin and gatifloxacin (P<0.05, P< 0.01); The top five doses of drug resistance are from low to high: strongmycin/methotromycin, oxycycline, gatifloxacin, methyl sulfomycin, and there is no significant difference between the five (P>0.05). In simple Uu infection, the top five sensitivity rates from high to low are: strongmycin/Mermomycin, thromycin, azithromycin and clarithromycin. The difference between the first three has no statistical significance (P>0.05). The difference between strong mythromycin/mectin and azithromycin or clarithromycin is statistically significant (P<0.0 1) The drug resistance rate is from low to high: oxycycline/methamycin, oxycycline, gatifloxacin, azithromycin/erythromycin/levofloxacin, and the resistance rate of oxymycin/methamphemycin is not statistically different from the latter two (P>0.05), and azithromycin/erythromycin/levofloxacin resistance. Rate differences are statistically significant (P<0.05). This study confirmed that when treating mycoplasma infection in the reproductive tract, we should try to choose mermondamycin, oxycycline or diamycin as much as possible. The alternative drugs for simple Mh and Uu infection are clindamycin and azithromycin respectively.