【摘 要】 目的 设计一款用于呼吸机内管路消毒的新型装置，并观察其消毒效果。方法 利用射流技术产生过氧化氢干雾的原理，设计一款串联式干雾过氧化氢呼吸机内管路消毒装置，并选取40台有传染特征患者使用过的呼吸机作为研究对象，在启动串联式干雾过氧化氢消毒之前、启动串联式干雾过氧化氢消毒1小时、启动串联式干雾过氧化氢消毒4小时三个时间节点对呼吸机进气口、出气口、内管道进行取样，进行菌落总数检测，以细菌总数≤20 cfu /件，不得检出致病菌，为消毒合格，并进行统计学分析。结果 检测结果显示，启动串联式干雾过氧化氢消毒之前，合格率为0%，启动串联式干雾过氧化氢消毒1小时和4小时后，各采集部位的菌落数显著低于消毒前（p＜0.05），且消毒合格率达到100%。结论 串联式干雾过氧化氢呼吸机内管路消毒装置消毒可靠、有效，消毒时长1小时可达到预期效果。

【Abstract】： Objective To develop a new disinfection device for the internal tubing of ventilators, and to assess its effectiveness. Methods The tandem device is designed to disinfect the internal tubing of ventilators with hydrogen peroxide (H2O2) dry mist that is produced by jet technique. The assessment was performed with 40 ventilators that were used by patients with infection. Cfu in air intake, air outlet, and internal tubing, was determined at the following time point, before disinfection, 1 hour after disinfection, and 4 hours after disinfection. The eligibility criteria were cfu<20 without any pathogenic bacteria. All data was subjected to statistical analysis. Results The qualified rate was 0% before disinfection by H2O2, while it was 100% after disinfection for 1 hour and 4 hours, and cfu in each detection sites was significantly lower after disinfection (p＜0.05). Conclusion The tandem H2O2 dry mist-disinfecting device is reliable and effective, and the expected effect could be achieved by 1-hour disinfection.