鲍曼不动杆菌外膜蛋白致病机制及其最新研究进展

喇嘉琪; 张晓蒙; 李如; 朝鲁门其其格

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微生物与感染 ›› 2025, Vol. 20 ›› Issue (1) : 59-64.

综述

鲍曼不动杆菌外膜蛋白致病机制及其最新研究进展

喇嘉琪¹,张晓蒙²,李如¹,朝鲁门其其格²

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The Pathogenic Mechanism of Outer Membrane Protein of Acinetobacter baumannii and Its Latest Research Progress

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文章历史 +

摘要

鲍曼不动杆菌（Acinetobacter baumannii，AB）是一种致病性极强的革兰氏阴性杆菌，不仅环境适应能力强，且存活期长，可对人体多部位造成感染，已凭借其强大的获得性耐药能力成为医院感染中最常见的病原体，故研究其致病机制迫在眉睫。其中，外膜蛋白是鲍曼不动杆菌致病的关键因素之一，其致病机制涵盖黏附与侵入、生物膜形成、免疫逃避、诱导细胞凋亡等。近年来，鲍曼不动杆菌外膜蛋白研究进展显著，新技术如蛋白质组学、基因转录组学、生物信息学等被广泛应用。本文将聚焦鲍曼不动杆菌外膜蛋白致病机制及其最新研究进展进行综述。

Abstract

Acinetobacter baumannii(AB) is a highly pathogenic Gram-negative bacterium with remarkable environmental adaptability and prolonged survival. It can infect multiple sites in the human body and has become one of the most common pathogens in hospital-acquired infections due to its extensive acquired drug resistance, making the study of its pathogenic mechanisms urgent. Outer membrane proteins (OMPs) are among the key virulence factors of AB, contributing to adhesion and invasion, biofilm formation, immune evasion, and induction of apoptosis. In recent years, significant progress has been made in research on AB OMPs, with advanced technologies such as proteomics, transcriptomics, and bioinformatics being widely applied. This review focuses on the pathogenic mechanisms of AB OMPs and the latest research advancements in this field.

导出引用

喇嘉琪张晓蒙李如朝鲁门其其格. 鲍曼不动杆菌外膜蛋白致病机制及其最新研究进展[J]. 微生物与感染. 2025, 20(1): 59-64

The Pathogenic Mechanism of Outer Membrane Protein of Acinetobacter baumannii and Its Latest Research Progress[J]. Journal of Microbes and Infections. 2025, 20(1): 59-64

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参考文献

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