具核梭杆菌与呼吸系统疾病关系的研究进展

唐怡; 魏美荣; 赵雪娟; 高慧

微生物与感染 ›› 2025, Vol. 20 ›› Issue (2) : 120-128.

综述

具核梭杆菌与呼吸系统疾病关系的研究进展

唐怡¹,魏美荣²,赵雪娟¹,高慧²

作者信息 +

Roles of Fusobacterium nucleatum in the Progression of Respiratory Diseases.

Author information +

文章历史 +

摘要

微生物与人类宿主之间的相互作用错综复杂，具核梭杆菌是人体共生菌，在病理条件下可导致慢性炎症反应，依靠其自身的多种黏附蛋白在菌斑形成和细菌致病性中发挥重要作用。近年来越来越多的证据表明牙周炎和呼吸系统疾病有关联，已在来自各种呼吸系统疾病的样本中检测到常见牙周病原体的存在，其通过促进呼吸道病原体的粘附和侵袭，促进呼吸道上皮细胞炎性反应和细胞凋亡，诱导粘蛋白过表达，破坏呼吸道免疫系统的平衡等影响呼吸系统疾病的发生和发展。在这篇综述中我们回顾了具核梭杆菌（Fusobacterium nucleatum，F. nucleatum）与呼吸系统疾病（主要是慢性阻塞性肺病、肺部感染性疾病、肺癌和支气管炎等）的关联，并总结分析了具核梭杆菌如何促进相关疾病进展的机制和分子改变，对挖掘对呼吸道疾病发病机制的新见解以及开发相关疾病的治疗和预防策略提供新的思路。

Abstract

The interaction between microorganisms and the human host is complex. Fusobacterium nucleatum, a commensal bacterium in the human body, can lead to chronic inflammatory responses under pathological conditions, playing an important role in plaque formation and bacterial pathogenicity through its various adhesion proteins. In recent years, increasing evidence has shown a link between periodontitis and respiratory diseases, with common periodontal pathogens detected in samples from various respiratory diseases. These pathogens can promote the adhesion and invasion of respiratory pathogens, enhance inflammatory responses and apoptosis in respiratory epithelial cells, induce mucin overexpression, and disrupt the balance of the respiratory immune system, thereby influencing the occurrence and development of respiratory diseases. In this review, we examine the association between Fusobacterium nucleatum and respiratory diseases (mainly chronic obstructive pulmonary disease, lung infectious diseases, lung cancer, and bronchitis) and summarize the mechanisms and molecular changes by which Fusobacterium nucleatum promotes the progression of related diseases. This provides new insights into the pathogenesis of respiratory diseases and offers new ideas for developing treatment and prevention strategies for these conditions.

导出引用

唐怡魏美荣赵雪娟高慧. 具核梭杆菌与呼吸系统疾病关系的研究进展[J]. 微生物与感染. 2025, 20(2): 120-128

Roles of Fusobacterium nucleatum in the Progression of Respiratory Diseases.[J]. Journal of Microbes and Infections. 2025, 20(2): 120-128

中图分类号： R56

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