蚊媒黄病毒与生殖健康

郭禹卿; 张家蔚; 贺诗淇; 安静; 盛子洋; 高娜

微生物与感染 ›› 2025, Vol. 20 ›› Issue (4) : 234-243.

综述

蚊媒黄病毒与生殖健康

郭禹卿¹,张家蔚¹,贺诗淇¹,安静²,盛子洋¹,高娜¹

作者信息 +

Mosquito-Borne Flaviviruses and Reproductive Health

Author information +

文章历史 +

摘要

蚊媒黄病毒是一大类具有包膜的单股正链RNA病毒，主要流行于热带和亚热带地区。目前，全球有超过30亿人生活在蚊媒黄病毒的流行区域，这些病毒对人类健康的威胁日益增加，其中最具代表性的包括寨卡病毒(Zika virus, ZIKV)、登革病毒(Dengue virus, DENV)、黄热病毒(Yellow fever virus, YFV）、西尼罗病毒(West Nile virus, WNV)和日本脑炎病毒(Japanese encephalitis virus, JEV)等。这些病毒不仅多次引发了大规模的疫情，并对人类的生殖健康及胎儿发育造成了显著影响。因此，本文将重点探讨上述病毒的基本特征及传播途径对生殖健康的潜在威胁，以期为公共卫生干预和个体防护提供科学参考。

Abstract

Mosquito-borne flaviviruses are a large group of enveloped, single-stranded, positive-sense RNA viruses that are primarily prevalent in tropical and subtropical regions. Currently, over three billion people worldwide live in endemic areas, posing a growing threat to human health. The most representative members of this group include Zika virus (ZIKV), dengue virus (DENV), yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV). These viruses have not only caused multiple large-scale outbreaks but have also significantly impacted human reproductive health and fetal development. Therefore, this article will focus on the basic characteristics of the aforementioned viruses and the potential threats their transmission routes pose to reproductive health, aiming to provide scientific references for public health interventions and individual protection.

导出引用

郭禹卿张家蔚贺诗淇安静盛子洋高娜. 蚊媒黄病毒与生殖健康[J]. 微生物与感染. 2025, 20(4): 234-243

Mosquito-Borne Flaviviruses and Reproductive Health[J]. Journal of Microbes and Infections. 2025, 20(4): 234-243

中图分类号： R373.3

参考文献

[1] Pierson TC, Diamond MS. The continued threat of emerging Flaviviruses[J]. Nat Microbiol， 2020;5(6):796-812. doi:10.1038/s41564-020-0714-0 [2] van Leur SW, Heunis T, Munnur D, Sanyal S. Pathogenesis and virulence of flavivirus infections[J]. Virulence，2021;12(1):2814-2838. doi:10.1080/21505594.2021.1996059 [3] 杨慧霞,狄文,朱兰.妇产科学[M].人民卫生出版社:202101:812. [4] Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014[J]. Euro Surveill,2014;19(13):20751. Published 2014 Apr 3. [5] Qin C, Wang Y, Liu M, Liu J. Global burden and incidence trends of zika virus infection among women aged 15-49 years from 2011 to 2021: A systematic analysis[J].Infect Public Health， 2024;17(11):102557. doi:10.1016/j.jiph.2024.102557 [6] Hamel R, Liégeois F, Wichit S, et al. Zika virus: epidemiology, clinical features and host-virus interactions[J]. Microbes Infect,2016;18(7-8):441-449. doi:10.1016/j.micinf.2016.03.009 [7] Calvet G, Aguiar RS, Melo ASO, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study[J]. Lancet Infect Dis, 2016;16(6):653-660. doi:10.1016/S1473-3099(16)00095-5 [8] Tabata T, Petitt M, Puerta-Guardo H, et al. Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission[J]. Cell Host Microbe, 2016;20(2):155-166. doi:10.1016/j.chom.2016.07.002 [9] Rubin EJ, Greene MF, Baden LR. Zika Virus and Microcephaly[J]. N Engl J Med, 2016;374(10):984-985. doi:10.1056/NEJMe1601862 [10] Brasil P, Pereira JP Jr, Moreira ME, et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro[J]. N Engl J Med, 2016;375(24):2321-2334. doi:10.1056/NEJMoa1602412 [11] Centeno-Tablante E, Medina-Rivera M, Finkelstein JL, et al. Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence[J].Viruses, 2021;13(1):123. Published 2021 Jan 18. doi:10.3390/v13010123 [12] Hanzlik E, Gigante J. Microcephaly[J]. Children (Basel), 2017;4(6):47. Published 2017 Jun 9. doi:10.3390/children4060047 [13] Counotte MJ, Meili KW, Taghavi K, Calvet G, Sejvar J, Low N. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review[J]. F1000Res, 2019;8:1433. Published 2019 Aug 14. doi:10.12688/f1000research.19918.1 [14] Vogel G. One year later, Zika scientists prepare for a long war[J]. Science, 2016;354(6316):1088-1089. doi:10.1126/science.354.6316.1088 [15] Yuan L, Huang XY, Liu ZY, et al. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly[J]. Science, 2017;358(6365):933-936. doi:10.1126/science.aam7120 [16] Aragao MFVV, Brainer-Lima AM, Holanda AC, et al. Spectrum of Spinal Cord, Spinal Root, and Brain MRI Abnormalities in Congenital Zika Syndrome with and without Arthrogryposis[J]. AJNR Am J Neuroradiol, 2017;38(5):1045-1053. doi:10.3174/ajnr.A5125 [17] Melo A S D O, Aguiar R S, Amorim M M R, et al. Congenital Zika Virus Infection[J]. JAMA Neurology, 2016,73(12):1407. doi: 10.1001/jamaneurol.2016.3720. [18] Cavalcanti DD, Alves LV, Furtado GJ, et al. Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study[J]. PLoS One, 2017;12(4):e0175065. Published 2017 Apr 20. doi:10.1371/journal.pone.0175065 [19] Freitas DA, Souza-Santos R, Carvalho LMA, et al. Congenital Zika syndrome: A systematic review[J]. PLoS One, 2020;15(12):e0242367. Published 2020 Dec 15. doi:10.1371/journal.pone.0242367 [20] Foy BD, Kobylinski KC, Chilson Foy JL, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA[J]. Emerg Infect Dis,2011;17(5):880-882. doi:10.3201/eid1705.101939 [21] Moreira J, Peixoto TM, Siqueira AM, Lamas CC. Sexually acquired Zika virus: a systematic review[J]. Clin Microbiol Infect, 2017;23(5):296-305. doi:10.1016/j.cmi.2016.12.027 [22] Atkinson B, Thorburn F, Petridou C, et al. Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016[J]. Emerg Infect Dis, 2017;23(4):611-615. doi:10.3201/eid2304.161692 [23] Arsuaga M, Bujalance SG, Díaz-Menéndez M, Vázquez A, Arribas JR. Probable sexual transmission of Zika virus from a vasectomised man[J]. Lancet Infect Dis, 2016;16(10):1107. doi:10.1016/S1473-3099(16)30320-6 [24] Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus[J].Emerg Infect Dis, 2015;21(2):359-361. doi:10.3201/eid2102.141363 [25] Joguet G, Mansuy JM, Matusali G, et al. Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study[J]. Lancet Infect Dis. 2017;17(11):1200-1208. doi:10.1016/S1473-3099(17)30444-9 [26] Gornet ME, Bracero NJ, Segars JH. Zika Virus in Semen: What We Know and What We Need to Know[J]. Semin Reprod Med, 2016;34(5):285-292. doi:10.1055/s-0036-1592312 [27] Ma W, Li S, Ma S, et al. Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice[J].Cell, 2017;168(3):542. doi:10.1016/j.cell.2017.01.009 [28] Uraki R, Jurado KA, Hwang J, et al. Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice[J]. J Infect Dis, 2017;215(11):1720-1724. doi:10.1093/infdis/jix204 [29] 杨威, 盛子洋, 吴艳花, 等. 寨卡病毒与男性(雄性)生殖健康[J]. 中国人兽共患病学报, 2019,35(06):545-551. [30] Siemann DN, Strange DP, Maharaj PN, Shi PY, Verma S. Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the In Vitro Blood-Testis Barrier Model[J]. J Virol, 2017;91(22):e00623-17. Published 2017 Oct 27. doi:10.1128/JVI.00623-17 [31] Kumar A, Jovel J, Lopez-Orozco J, et al. Human Sertoli cells support high levels of Zika virus replication and persistence[J]. Sci Rep, 2018;8(1):5477. Published 2018 Apr 3. doi:10.1038/s41598-018-23899-x [32] Clancy CS, Van Wettere AJ, Siddharthan V, Morrey JD, Julander JG. Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar-/- Mice[J]. Am J Pathol, 2018;188(4):904-915. doi:10.1016/j.ajpath.2017.12.019 [33] Prow NA, Liu L, Nakayama E, et al. A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses[J]. Nat Commun, 2018;9(1):1230. Published 2018 Mar 26. doi:10.1038/s41467-018-03662-6 [34] Mulik V, Dad N, Buhmaid S. Dengue in pregnancy: Review article[J]. Eur J Obstet Gynecol Reprod Biol. 2021;261:205-210. doi:10.1016/j.ejogrb.2021.04.035 [35] Martin BM, Evans AA, de Carvalho DS, Shimakura SE. Clinical outcomes of dengue virus infection in pregnant and non-pregnant women of reproductive age: a retrospective cohort study from 2016 to 2019 in Paraná, Brazil[J]. BMC Infect Dis, 2022;22(1):5. Published 2022 Jan 4. doi:10.1186/s12879-021-06985-w [36] Goicochea-Ríos EDS, Otiniano NM, Rojas-Infantas LDC, Oca?a-Gutiérrez VR, Gómez- Goicochea NI. Dengue infection during pregnancy and the occurrence of pathological neonatal outcome: a systematic review and meta-analysis[J]. F1000Res, 2025;13:1523. Published 2025 Aug 26. doi:10.12688/f1000research.158890.3 [37] 崔晓荣, 张延丽. 危重孕产妇病因分析及救治措施[J]. 医学综述, 2021,27(02):365-368. [38] Basurko C, Everhard S, Matheus S, et al. A prospective matched study on symptomatic dengue in pregnancy[J]. PLoS One, 2018;13(10):e0202005. Published 2018 Oct 3. doi:10.1371/journal.pone.0202005 [39] Tagore S, Yim CF, Kwek K. Dengue haemorrhagic fever complicated by eclampsia in pregnancy[J].Singapore Med J, 2007;48(10):e281-e283. [40] Ahuja S, Muntode Gharde P. A Narrative Review of Maternal and Perinatal Outcomes of Dengue in Pregnancy[J]. Cureus, 2023;15(11):e48640. Published 2023 Nov 11. doi:10.7759/cureus.48640 [41] Chye J K, Lim C T, Ng K B, et al. Vertical transmission of dengue[J]. Clin Infect Dis, 1997,25(6):1374-1377. DOI: 10.1086/516126. [42] Kim IJ, Tighe MP, Clark MJ, et al. Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets[J]. Sci Transl Med,2023;15(699):eabq6517. doi:10.1126/scitranslmed.abq6517 [43] Basurko C, Carles G, Youssef M, Guindi WE. Maternal and fetal consequences of dengue fever during pregnancy[J]. Eur J Obstet Gynecol Reprod Biol, 2009;147(1):29-32. doi:10.1016/j.ejogrb.2009.06.028 [44] Basurko C, Matheus S, Hildéral H, et al. Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study[J]. Am J Trop Med Hyg, 2018;98(6):1826-1832. doi:10.4269/ajtmh.16-0794 [45] Ribeiro CF, Lopes VG, Brasil P, Coelho J, Muniz AG, Nogueira RM. Perinatal transmission of dengue: a report of 7 cases[J]. J Pediatr, 2013;163(5):1514-1516. doi:10.1016/j.jpeds.2013.06.040 [46] Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus Infection[J]. Immunology, 2017;151(3):261-269. doi:10.1111/imm.12748 [47] Ribeiro CF, Lopes VGS, Brasil P, Pires ARC, Rohloff R, Nogueira RMR. Dengue infection in pregnancy and its impact on the placenta[J]. Int J Infect Dis, 2017;55:109-112. doi:10.1016/j.ijid.2017.01.002 [48] Angelin M, Sj?lin J, Kahn F, et al. Qdenga? - A promising dengue fever vaccine; can it be recommended to non-immune travelers?[J]. Travel Med Infect Dis. 2023;54:102598. doi:10.1016/j.tmaid.2023.102598 [49] Skipetrova A, Wartel TA, Gailhardou S. Dengue vaccination during pregnancy - An overview of clinical trials data[J]. Vaccine, 2018;36(23):3345-3350. doi:10.1016/j.vaccine.2018.04.050 [50] Liew CH. The first case of sexual transmission of dengue in Spain[J]. J Travel Med, 2020;27(1):taz087. doi:10.1093/jtm/taz087 [51] Mons J, Mahé-Poiron D, Mansuy JM, et al. Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men[J]. Emerg Infect Dis,2022;28(6):1146-1153. doi:10.3201/eid2806.212317 [52] Molton JS, Low I, Choy MMJ, et al. Dengue virus not detected in human Semen[J]. J Travel Med,2018;25(1):10.1093/jtm/tay023. doi:10.1093/jtm/tay023 [53] Tuells J, Henao-Martínez AF, Franco-Paredes C. Yellow Fever: A Perennial Threat[J]. Arch Med Res, 2022;53(7):649-657. doi:10.1016/j.arcmed.2022.10.005 [54] Marinho PS, Cunha AJ, Amim Junior J, Prata-Barbosa A. A review of selected Arboviruses during pregnancy[J]. Matern Health Neonatol Perinatol, 2017;3:17. Published 2017 Oct 3. doi:10.1186/s40748-017-0054-0 [55] Tsai TF, Paul R, Lynberg MC, Letson GW. Congenital yellow fever virus infection after immunization in pregnancy[J]. J Infect Dis. 1993;168(6):1520-1523. doi:10.1093/infdis/168.6.1520 [56] Chart H, Cheasty T. Human infections with verocytotoxin-producing Escherichia coli O157— 10 years of E. coli O157 serodiagnosis[J]. J Med Microbiol, 2008;57(Pt 11):1389-1393. doi:10.1099/jmm.0.2008/003632-0 [57] Desgraupes S, Hubert M, Gessain A, Ceccaldi PE, Vidy A. Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms[J]. Viruses, 2021;13(7):1312. Published 2021 Jul 7. doi:10.3390/v13071312 [58] Barbosa CM, Di Paola N, Cunha MP, et al. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil[J]. Emerg Infect Dis, 2018;24(1):176-178. doi:10.3201/eid2401.171310 [59] Sirois PA, Pridjian G, McRae S, et al. Developmental outcomes in young children born to mothers with West Nile illness during pregnancy[J]. Birth Defects Res A Clin Mol Teratol, 2014;100(10):792-796. doi:10.1002/bdra.23297 [60] Centers for Disease Control and Prevention (CDC). Intrauterine West Nile virus infection— New York, 2002[J]. MMWR Morb Mortal Wkly Rep, 2002;51(50):1135-1136. [61] Alpert SG, Fergerson J, No?l LP. Intrauterine West Nile virus: ocular and systemic findings[J]. Am J Ophthalmol, 2003;136(4):733-735. doi:10.1016/s0002-9394(03)00452-5 [62] Córdoba L, Escribano-Romero E, Garmendia A, Saiz JC. Pregnancy increases the risk of mortality in West Nile virus-infected mice[J]. J Gen Virol, 2007;88(Pt 2):476-480. doi:10.1099/vir.0.82439-0 [63] Jamieson DJ, Jernigan DB, Ellis JE, Treadwell TA. Emerging infections and pregnancy: West Nile virus, monkeypox, severe acute respiratory syndrome, and bioterrorism[J]. Clin Perinatol, 2005;32(3):765-776. doi:10.1016/j.clp.2005.04.008 [64] Centers for Disease Control and Prevention (CDC). Possible West Nile virus transmission to an infant through breast-feeding--Michigan, 2002[J]. MMWR Morb Mortal Wkly Rep, 2002;51(39):877-878. [65] Payne K, Kenny P, Scovell JM, Khodamoradi K, Ramasamy R. Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men[J]. Sex Med Rev, 2020;8(4):518-530. doi:10.1016/j.sxmr.2020.06.003 [66] Amicizia D, Zangrillo F, Lai PL, Iovine M, Panatto D. Overview of Japanese encephalitis disease and its prevention. Focus on IC51 vaccine (IXIARO?)[J]. J Prev Med Hyg, 2018;59(1):E99-E107. Published 2018 Mar 30. doi:10.15167/2421-4248/jpmh2018.59.1.962 [67] Chaturvedi UC, Mathur A, Chandra A, Das SK, Tandon HO, Singh UK. Transplacental infection with Japanese encephalitis virus[J]. J Infect Dis, 1980;141(6):712-715. doi:10.1093/infdis/141.6.712 [68] Hills SL, Walter EB, Atmar RL, Fischer M; ACIP Japanese Encephalitis Vaccine Work Group. Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices[J]. MMWR Recomm Rep, 2019;68(2):1-33. Published 2019 Jul 19. doi:10.15585/mmwr.rr6802a1 [69] Khodr ZG, Hall C, Chang RN, Bukowinski AT, Gumbs GR, Conlin AMS. Japanese encephalitis vaccination in pregnancy among U.S. active duty military women[J]. Vaccine, 2020;38(29):4529-4535. doi:10.1016/j.vaccine.2020.05.023 [70] Habu A, Murakami Y, Ogasa A, Fujisaki Y[J]. Uirusu, 1977;27(1):21-26. doi:10.2222/jsv.27.21 [71] Chapagain S, Pal Singh P, Le K, Safronetz D, Wood H, Karniychuk U. Japanese encephalitis virus persists in the human reproductive epithelium and porcine reproductive tissues[J]. PLoS Negl Trop Dis, 2022;16(7):e0010656. Published 2022 Jul 29. doi:10.1371/journal.pntd.0010656