微针作为一种高效的经皮免疫方式，可以穿透角质层，在不损害神经血管的情况下，将抗原递送至免疫细胞丰富的真皮层。其中，可溶性微针(dissolving microneedles, dMNs)由于制备简单、操作便捷、载药量大、不产生针尖废弃物等诸多优点而备受关注。本文总结了dMNs疫苗的免疫效果及目前的临床试验进展，同时探讨了dMNs在使用过程中存在的问题并展望未来的研究方向，以期为dMNs疫苗的相关研究提供参考，并推动其实际应用。

Microneedles, as an efficient transdermal immunization modality, can penetrate the stratum corneum and deliver antigens to the immune cell-rich dermis without damaging the neurovascular system. Among them, dissolving microneedles (dMNs) have attracted much attention due to many advantages such as simple preparation, convenient operation, high drug capacity, and less tip waste. In this review, we mainly summarized the immune effect of dMNs vaccines and the current progress of clinical trials, discussed the issues that exist during the use of dMNs and looked forward to the future research, so as to provide a reference for the research of dMNs vaccination and promote its application.