新型隐球菌感染导致危重型脑膜炎病例1例

谢芸琦; 袁运生; 林小华; 黄镭; 饶丽樱; 刘真怡; 索质君; 余治健; 陈重

doi:10.3969/j.issn.1673-6184.2024.04.005

微生物与感染 >

2024 , Vol. 19 >Issue 4: 227 - 231

DOI: https://doi.org/10.3969/j.issn.1673-6184.2024.04.005

病例分析

新型隐球菌感染导致危重型脑膜炎病例1例

谢芸琦 ,
袁运生 ,
林小华 ,
黄镭 ,
饶丽樱 ,
刘真怡 ,
索质君 ,
余治健 ,
陈重

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1. 深圳市南山区人民医院感染科，广东深圳 518052; 2. 深圳市内源性感染诊治研究重点实验室，广东深圳 518052; 3. 深圳市南山区人民医院重症医学部，广东深圳 518052

收稿日期: 2023-11-28

修回日期: 2024-05-29

网络出版日期: 2024-08-25

基金资助

广东省自然科学基金项目(2020A1515111146)；深圳市科创委面上项目(JCYJ20220530141614034)；深圳市南山区科技局项目(NS2023008)

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Severe meningitis caused by Cryptococcus neoformans infection: a case report

XIE Yun-Qi ,
YUAN Yun-Sheng ,
LIN Xiao-Hua ,
HUANG Lei ,
RAO Li-Ying ,
LIU Zhen-Yi ,
SUO Zhi-Jun ,
YU Yi-Jian ,
CHEN Tong

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1. Department of Infectious Disease, Shenzhen Nanshan People’s Hospital, Shenzhen 518052, Guangdong Province，China; 2. Shenzhen Key Lab for Endogenous Infection, Shenzhen 518052, Guangdong Province，China; 3. Intensive Care Unit, Shenzhen Nanshan People’s Hospital, Shenzhen 518052, Guangdong Province，China

Received date: 2023-11-28

Revised date: 2024-05-29

Online published: 2024-08-25

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摘要

隐球菌(Cryptococcus)是一种机会致病菌，能引起免疫功能低下的患者感染隐球菌性脑膜炎(cryptococcal meningitis)。隐球菌主要导致亚急性或慢性感染，急性病程少见，本文介绍了1例糖尿病患者由新型隐球菌急性感染导致脑膜炎进行性加重的病例，旨在了解影响隐球菌性脑膜炎预后不良的因素。

关键词： 隐球菌性脑膜炎; 颅内压升高; 糖尿病; 抗真菌治疗

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谢芸琦 , 袁运生 , 林小华 , 黄镭 , 饶丽樱 , 刘真怡 , 索质君 , 余治健 , 陈重 . 新型隐球菌感染导致危重型脑膜炎病例1例[J]. 微生物与感染, 2024 , 19(4) : 227 -231 . DOI: 10.3969/j.issn.1673-6184.2024.04.005

Abstract

Cryptococcus is an opportunistic pathogen that causes cryptococcal meningitis in immunocompromised patients. Cryptococcus mainly causes subacute or chronic infection, but the acute course is rare. This article introduced a case of progressive exacerbation of meningitis caused by acute infection of Cryptococcus neoformans in a diabetic patient, and to understand the factors affecting the poor prognosis of cryptococcal meningitis.

Key words： Cryptococcus neoformans meningitis; Intracranial hypertension; Diabetes; Antifungal therapy

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