本文主要研究上海市宝山区吴淞地区门诊与住院女性患者人型支原体(Mycoplasma hominis, Mh)与解脲支原体(Ureaplasma urealyticum, Uu)感染及药敏情况，旨在为临床诊治工作提供科学依据。采用支原体培养鉴定计数药敏试剂盒，对413例样本进行支原体培养、鉴定和药敏试验，共检出支原体阳性标本178例(43.10%)，其中单纯Mh感染17例(4.12%)，单纯Uu感染152例(36.80%)，混合感染9例(2.18%)。单纯Mh感染时，抗菌药物高敏率前5位由高到低依次为：多西环素/米诺环素、交沙霉素、克林霉素、加替沙星，前三者的敏感率无显著性差异(P>0.05)，多西环素/米诺环素与克林霉素、加替沙星有显著性差异(P<0.05，P<0.01)；耐药率前5位由低到高依次为：多西环素/米诺环素、交沙霉素、加替沙星、甲砜霉素，五者之间无显著性差异(P>0.05)。单纯Uu感染时，高敏率前5位由高到低依次为：多西环素/米诺环素、交沙霉素、阿奇霉素、克拉霉素，前三者差异无统计学意义(P>0.05)，多西环素/米诺环素与阿奇霉素或克拉霉素差异有统计学意义(P<0.01)；耐药率由低到高依次为：多西环素/米诺环素、交沙霉素、加替沙星、阿奇霉素/红霉素/左氧氟沙星，多西环素/米诺环素的耐药率与交沙霉素、加替沙星差异无统计学意义(P>0.05)，与阿奇霉素/红霉素/左氧氟沙星耐药率差异有统计学意义(P<0.05)。本地区治疗生殖道支原体感染时，应尽量选择米诺环素、多西环素或交沙霉素，单纯Mh和Uu感染的备选药物分别是克林霉素和阿奇霉素。

The infection and drug sensitivity of Mycoplasma hominis (Mh) and Ureaplasma urealyticum (Uu) in outpatient and inpatient female patients in the Wusong area of Baoshan, Shanghai were studied to provide a scientific evidence for clinical diagnosis and treatment. Mycoplasma culture identification and count drug sensitivity kits were used to carry out Mycoplasma culture, identification and drug susceptible test. A total of 413 cases underwent Mycoplasma culture and drug sensitivity test, of which 178 cases were positive for mycoplasma culture (43.10%), 17 cases with simple Mh infection (4.12%), 152 cases with simple Uu infection (36.80%), and 9 cases with mixed infection (2.18%). In simple Mh infection, the top five high-sensitivity rates from high to low are: doxytetramycin/minocycline, josamycin, clindamycin and gatifloxacin. There is no significant difference in the sensitivity rates of the first three drugs (P>0.05). There is a significant difference between doxytetramycin/minocycline and clindamycin or gatifloxacin (P<0.05, P<0.01). The top five drug resistance rates from low to high are: doxytetramycin/minocycline, josamycin, gatifloxacin, thiamphenicol, and there is no significant difference in the resistance rate of the five drugs (P>0.05). In simple Uu infection, the top five high-sensitivity rates from high to low are: doxytetramycin/minocycline, josamycin, azithromycin and clarithromycin. The difference between the first three drugs has no statistical significance (P>0.05). The difference between doxytetramycin/minocycline and azithromycin or clarithromycin is statistically significant (P<0.01). The drug resistance rates from low to high are: doxytetramycin/minocycline, josamycin, gatifloxacin, azithromycin/erythromycin/levofloxacin, and the resistance rate of doxytetramycin/minocycline is not statistically different from the latter two drugs (P>0.05), and is statistically different from azithromycin/erythromycin/levofloxacin (P<0.05). When treating mycoplasma infections of the reproductive tract, the clinicians should try to choose minocycline, doxytetramycin or josamycin. The alternative drugs for simple Mh and Uu infections are clindamycin and azithromycin respectively.