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综述

SARS-CoV-2细胞受体的研究进展

  • 陈生林1* ,
  • 肖蔓2 * ,
  • 李赵忠3 ,
  • 徐志凯1 ,
  • 韩起1 ,
  • 冯东方1 ,
  • 邓雁1 ,
  • 殷作明1
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  • 1. 中国人民解放军西藏军区总医院, 西藏 拉萨 850007; 2. 成都西区医院, 四川 成都 610036; 3. 中国人民解放军西部战区总医院, 四川 成都 610083

收稿日期: 2022-08-24

  网络出版日期: 2023-02-25

基金资助

军队重点课题(BLB18J008)

Recent progress on cell receptors for SARS-CoV-2

  • CHEN Shenglin1* ,
  • XIAO Man2* ,
  • LI Zhaozhong3 ,
  • XU Zhikai1 ,
  • HAN Qi1 ,
  • FENG Dongfang1 ,
  • DENG Yan1 ,
  • YIN Zuoming1
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  • 1. General Hospital of Tibet Military Area Command of PLA, Lhasa 850007, Tibet Autonomous Region, China; 2. Chengdu Western Hospital, Chengdu 610036, Sichuan Province, China; 3. General Hospital of Western Theater Command of PLA, Chengdu 610083, Sichuan Province, China

Received date: 2022-08-24

  Online published: 2023-02-25

摘要

严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)是引起2019冠状病毒病(coronavirus disease 2019,COVID-19)的病原体,在人群中广泛持久传播,对人类健康和社会经济造成了巨大危害。目前,针对COVID-19的治疗尚无特异高效的抗病毒药物。病毒为实现寄生感染,通常先与宿主细胞膜表面受体结合,进而内化入胞。因此,SARS-CoV-2受体决定着病毒的感染特性和宿主范围,对其进行研究和解析是战胜SARS-CoV-2感染的一个关键手段。SARS-CoV-2受体的发现和鉴定,将为COVID-19提供新的治疗靶点。本文主要对SARS-CoV-2入侵受体及黏附受体的研究进展进行综述。

本文引用格式

陈生林1* , 肖蔓2 * , 李赵忠3 , 徐志凯1 , 韩起1 , 冯东方1 , 邓雁1 , 殷作明1 . SARS-CoV-2细胞受体的研究进展[J]. 微生物与感染, 2023 , 18(1) : 46 -54 . DOI: 10.3969/j.issn.1673-6184.2023.01.006

Abstract

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the coronavirus disease 2019(COVID-19), which spreads rapidly in humans and endangers global health and economy. There are no specific and effective antiviral drugs for the treatment of COVID-19 currently. To infect host cells successfully for a virus, receptor binding and virus internalization are considered to be the initial steps. A key to combat SARS-CoV-2 infection is to investigate the viral receptors, which determine its infectivity and host range. The discovery and identification of cell receptors for SARS-CoV-2 will provide new therapeutic targets for COVID-19. This article reviews the recent findings on the entry and attachment receptors for SARS-CoV-2.
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