Etiological analysis of pulmonary alveolar lavage fluid in hospitalized children with consolidated pneumonia
LI Fei1, ZHU Qiguo2, SHI Peng3, CAO Lingfen4, WANG Libo5, LU Roujian6, TAN Wenjie6, SHEN Jun1
1. Infectious Disease Department, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China; 2. Respiratory Department, Children’s Hospital Xiamen Branch, Xia Men 361006, Fujian Province, China; 3. Department of Statistics and Data Management, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China; 4. Virology Department, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China; 5. Respiratory Department, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China; 6. Key Laboratory of Medical Virology, Ministry of the Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
Abstract：The purpose of this study is to analyze the pathogenic spectrum of children’s pneumonia with pulmonary consolidation, and provide information for clinical empirical anti-infection treatment. From January 2019 to January 2020, the clinical data of hospitalized children with pneumonia diagnosed who underwent fiberoptic bronchoscopy in our center were retrospectively reviewed. By the reading of two senior pediatric infectious doctors, the data of pathogens detection result of bronchoalveolar lavage fluid (BALF) from children with pneumonia and/or pulmonary consolidation were analyzed. The diagnosis of lung consolidation was based on imaging evidence. 286 BALF samples from 286 children with mean age of 5.5 (5.8±3.1) years were detected. 195 cases (68.2%) with pulmonary consolidation. The positive detection rates of pathogens in all patients were 76.6% (219/286). The positive detection rates of patients with or without pulmonary consolidation were 77.9%(152/195)and 73.6%(67/91)respectively (P>0.05). Mycoplasma pneumoniae, adenovirus, rhinovirus, respiratory syncytial virus and parainfluenza virus type 3 were the top five detected pathogens. Mycoplasma pneumoniae got the highest positive rate 77.0%(127/165)in children of 5 years old and above. The detection rates of mycoplasma pneumoniae in patients with or without pulmonary consolidation were 67.2% (131/195) and 61.5% (56/91), respectively, (P>0.05). Mycoplasma pneumoniae, adenovirus, rhinovirus, respiratory syncytial virus and parainfluenza virus type 3 infection were the dominant etiology of children’s pneumonia in the target population. The pathogens detection rates were similar in patients with or without pulmonary consolidation.
李飞1，朱其国2，施鹏3，曹凌峰4，王立波5，陆柔剑6，谭文杰6，沈军1. 儿童肺炎肺实变住院患儿支气管肺泡灌洗液病原分析[J]. 微生物与感染, 2021, 16(5): 331-338.
LI Fei1, ZHU Qiguo2, SHI Peng3, CAO Lingfen4, WANG Libo5, LU Roujian6, TAN Wenjie6, SHEN Jun1. Etiological analysis of pulmonary alveolar lavage fluid in hospitalized children with consolidated pneumonia. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(5): 331-338.
2021, Vol. 16 
