Analysis of distribution and antimicrobial resistance of pathogenic bacteria in 1396 patients' blood cultures in a tertiary first-class hospital in Shanghai during 2014-2021
Abstract：To provide reference for rational use of antibiotics in clinic, we investigate the distribution and antimicrobial resistance of pathogens causing bloodstream infection. The main pathogenic bacteria isolated from positive blood culture specimens and their antimicrobial resistance in our hospital from 2014 to 2021 were statistically analyzed. After eliminating the duplicate strains, a total of 1396 strains of pathogenic bacteria were detected in blood culture samples during the past eight years. The gram-negative bacteria, gram-positive bacteria and fungi account for 56.3%, 38.4% and 5.3%, respectively. The top eight strains were Escherichia coli accounting for 21.5% (300/1396), Coagulase negative Staphylococcus (CNS) accounting for 17.4% (243/1396), Klebsiella pneumoniae accounting for 14.9% (208/1396), Staphylococcus aureus accounting for 7.2% (100/1396), Acinetobacter baumannii accounting for 5.4% (76/1396), Enterococcus faecalis accounting for 4.2% (58/1396), Enterococcus faecium accounting for 3.7% (51/1396) and Pseudomonas aeruginosa accounting for 3.5% (49/1396). The resistance rate of Escherichia coli to third-generation cephalosporins exceeded 50%, and the resistance rate to carbapenems was as low as 1%; The resistance rate of Klebsiella pneumoniae to carbapenems was 46.3%; The cumulative resistance rate of Acinetobacter baumannii to cephalosporins, aminoglycosides and carbapenems was more than 45%; The cumulative rates of MRSA and CNS were 44.6% and 74.5%, respectively.
Goto M, Al-Hasan M N.Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe[J].Clin Microbiol Infect, 2013, 19(6):501-509
[2]
Mcnamara J F, Righi E, Wright H, et al.Long-term morbidity and mortality following bloodstream infection: A systematic literature review[J].J Infect, 2018, 77(1):1-8
[3]
Institute C A L S.Performance Standards for Antimicrobial Susceptibility Testing, 30th Edition. M100-Ed30[J]. 2020.
Huttunen R, Attman E, Aittoniemi J, et al.Nosocomial bloodstream infections in a Finnish tertiary care hospital: a retrospective cohort study of 2175 episodes during the years 1999-2001 and 2005-2010[J].Infect Dis (Lond), 2015, 47(1):20-26
[7]
Musicha P, Cornick J E, Bar-Zeev N, et al.Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi (1998-2016): a surveillance study[J].Lancet Infect Dis, 2017, 17(10):1042-1052
[8]
Tian L, Sun Z, Zhang Z.Antimicrobial resistance of pathogens causing nosocomial bloodstream infection in Hubei Province,China,from 2014 to 2016: a multicenter retrospective study[J].BMC Public Health, 2018, 18(1):1121-
Wu HG, Liu WS, Zhu M, et al.Research and analysis of 74 bloodstream infection cases of Acinetobacter baumannii and drug resistance.Eur Rev Med Pharmacol Sci, 2018; 22:1782～1786.[J].Eur Rev Med Pharmacol Sci, 2018, 22(6):1782-1786
