本文探讨了铁离子在淋病奈瑟球菌(以下简称“淋球菌”)感染宿主过程中的作用，旨在为淋病防治提供思路。搜索知网、万方、维普、PubMed 4大数据库，查阅铁离子在淋球菌感染宿主过程中的调节作用及其与细菌耐药相关的文献。从淋球菌黏附、竞争铁离子、抵抗宿主免疫系统杀伤以及人群间传播等方面分析显示：淋球菌内铁含量减少可下调细菌对宿主体内抗菌物质的敏感性；菌内铁含量较低时可通过上调铁摄取基因表达，分泌转铁蛋白/乳铁蛋白结合蛋白、铁载体、MpeR等物质，从宿主糖蛋白内抢夺铁离子，促进淋球菌在宿主细胞内的存活和播散。铁离子在淋球菌基本生存需求、抵御杀伤、传播播散等方面都发挥了重要作用。调节菌体内、外铁离子的浓度可增强淋球菌感染的防治效果。

This study explored the role of iron ion in the infection process of Neisseria gonorrhoeae on host to provide ideas for the prevention and treatment of gonorrhea. It consulted the four major databases of CNKI, Wanfang, VIP and PubMed to search for the regulatory role of iron ion in the infection process of Neisseria gonorrhoeae on host and its correlation with drug resistance. The analysis from the aspects of Neisseria gonorrhoeae adhesion, competition for iron ion, resistance to host killing and human-to-human transmission showed that Neisseria gonorrhoeae decreased its sensitivity to host antibacterial substances by reducing the content of iron in the bacteria. When the iron content is low, Neisseria gonorrhoeae can promote the survival and dissemination by up-regulating the expression of iron uptake gene and secreting transferrin / lactoferrin binding protein, iron carrier, MpeR and other substances. As a result, iron ions play an important role in Neisseria gonorrhoeae’s basic survival needs, resistance to killing, spread and so on. Regulating the concentration of iron ions inside and outside the bacterial cells can increase the prevention and treatment effect on Neisseria gonorrhoeae infection.