The role of iron ions in the infection process of Neisseria gonorrhoeae on host
GUO Huaqi1，WANG Yanqing2
1. Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 2. Department of Dermatology, Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Abstract：This study explored the role of iron ion in the infection process of Neisseria gonorrhoeae on host to provide ideas for the prevention and treatment of gonorrhea. It consulted the four major databases of CNKI, Wanfang, VIP and PubMed to search for the regulatory role of iron ion in the infection process of Neisseria gonorrhoeae on host and its correlation with drug resistance. The analysis from the aspects of Neisseria gonorrhoeae adhesion, competition for iron ion, resistance to host killing and human-to-human transmission showed that Neisseria gonorrhoeae decreased its sensitivity to host antibacterial substances by reducing the content of iron in the bacteria. When the iron content is low, Neisseria gonorrhoeae can promote the survival and dissemination by up-regulating the expression of iron uptake gene and secreting transferrin / lactoferrin binding protein, iron carrier, MpeR and other substances. As a result, iron ions play an important role in Neisseria gonorrhoeae’s basic survival needs, resistance to killing, spread and so on. Regulating the concentration of iron ions inside and outside the bacterial cells can increase the prevention and treatment effect on Neisseria gonorrhoeae infection.
郭华琦1, 王艳青2. 铁离子在淋病奈瑟球菌感染宿主过程中的作用[J]. 微生物与感染, 2023, 18(5): 307-311.
GUO Huaqi1，WANG Yanqing2. The role of iron ions in the infection process of Neisseria gonorrhoeae on host. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(5): 307-311.
2023, Vol. 18 
