Abstract:Abstract: To explore the role of iron ion in the host process of Neisseria gonorrhoeae infection, and to provide ideas for the prevention and treatment of gonorrhea. Consult the four major databases of CNKI, Wanfang, VIP and PubMed to search for the regulatory role of iron ion in the host process of Neisseria gonorrhoeae infection and its correlation with drug resistance. The analysis from the aspects of Neisseria gonorrhoeae adhesion, competition for iron ion, resistance to host killing and human-to-human transmission showed that Neisseria gonorrhoeae decreased its sensitivity to host antibacterial substances by reducing the content of iron in the bacteria. When the iron content is low, Neisseria gonorrhoeae can promote the survival and dissemination of Neisseria gonorrhoeae by up-regulating the expression of iron uptake gene and secreting transferrin / lactoferrin binding protein, iron carrier, MpeR and other substances. As a result, iron ions play an important role in Neisseria gonorrhoeae basic survival needs, resistance to killing, spread and so on. By regulating the concentration of iron ions inside and outside the bacteria, the disease prevention effect can be enhanced.
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